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Abstract

Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.

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PubMed ID:: 18194646

DOI:: 10.1016/j.devcel.2007.12.014

ScienceOpen disciplines: Chemistry

Keywords: Animals,Endosomes,physiology,Golgi Apparatus,Models, Biological,Signal Transduction,Transport Vesicles,metabolism,Vesicular Transport Proteins,Wnt Proteins,trans-Golgi Network

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Endosomes, physiology, Golgi Apparatus, Models, Biological, Signal Transduction, Transport Vesicles, metabolism, Vesicular Transport Proteins, Wnt Proteins, trans-Golgi Network

Retromer retrieves wntless.

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