Radio-Fibrinogen Studies in Renal Hypertension

Abstract

The aorta of hypertensive rabbits has an increased content of water, sodium and fibrinogen. Fibrinogen catabolism is normal in most hypertensive animals and is, therefore, not a concomitant of increased vascular permeability but accelerated catabolism can be demonstrated when there is associated shock, red cell fragmentation due to DOCA angiopathy, hypertension in pregnancy, coincidental anoxia and acidosis, or in terminal uraemia. Under all these conditions, fibrin is deposited particularly in the kidney and may, therefore lead to further renal ischaemia.