Human ESC-Derived Interneurons Improve Major Consequences of Spinal Cord Injury.

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Abstract

Beyond impaired motor and sensory function, neuropathic pain and loss of bladder control caused by spinal cord injuries (SCIs) can severely affect quality of life. In this issue of Cell Stem Cell, Fandel et al. (2016) show that transplanted human ESC-derived cells biased to produce inhibitory interneurons significantly improve pain and bladder function in rodent SCI models.

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Journal

Journal ID (iso-abbrev): Cell Stem Cell

Title: Cell stem cell

Publisher: Elsevier BV

ISSN (Electronic): 1875-9777

ISSN (Print): 1875-9777

Publication date (Electronic): Oct 06 2016

Volume: 19

Issue: 4

Affiliations

[1 ] Department of Neurological Surgery and Goodman Campbell Brain and Spine, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indianapolis, IN 46202, USA. Electronic address: ablesch@iupui.edu.

Article

Publisher Item ID: S1934-5909(16)30302-2

DOI: 10.1016/j.stem.2016.09.008

PubMed ID: 27716521

SO-VID: 56614330-8f1c-4675-a479-b7aceb5855ca

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