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      Human ESC-Derived Interneurons Improve Major Consequences of Spinal Cord Injury.

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      Cell stem cell

      Elsevier BV

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          Abstract

          Beyond impaired motor and sensory function, neuropathic pain and loss of bladder control caused by spinal cord injuries (SCIs) can severely affect quality of life. In this issue of Cell Stem Cell, Fandel et al. (2016) show that transplanted human ESC-derived cells biased to produce inhibitory interneurons significantly improve pain and bladder function in rodent SCI models.

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          Author and article information

          Journal
          Cell Stem Cell
          Cell stem cell
          Elsevier BV
          1875-9777
          1875-9777
          Oct 06 2016
          : 19
          : 4
          Affiliations
          [1 ] Department of Neurological Surgery and Goodman Campbell Brain and Spine, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indianapolis, IN 46202, USA. Electronic address: ablesch@iupui.edu.
          Article
          S1934-5909(16)30302-2
          10.1016/j.stem.2016.09.008
          27716521

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