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      Osteoscintigraphic Changes in Kidney-Transplanted Patients

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          Abstract

          Technetium-99m-polyphosphate bone scintigraphy was performed in 105 kidney-transplanted patients. The pathological scintigraphic changes were classified as either (1) generalized, symmetrical or (2) focal accumulations of the tracer in the bones. 40 of the patients had normal scintigrams. 18 patients had generalized symmetrical scintigraphic changes alone, while focal scintigraphic changes were found in 14 patients without generalized changes and 33 patients had generalized as well as focal changes. The severity of the scintigraphic findings correlated to the results of the transplantation, i.e. the total dose of prednisone, the number of rejection episodes and the creatinine clearance at the time of scintigraphy. Compared to patients on hemodialysis a less frequent appearance of generalized scintigraphic changes was found in kidney-transplanted patients, suggesting that the frequency of renal osteodystrophy decreases after a successful transplantation. The more frequent appearance of focal changes after a kidney transplantation suggests that a bone disease of a different etiology now is superimposed. As both types of scintigraphic changes showed highly significant correlations to the total dose of prednisone, it is concluded that glucocorticoid treatment is an important etiological factor in the development of focal bone lesions and may contribute to the maintenance of generalized skeletal lesions after a kidney transplantation.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 21
          : 2
          : 86-94
          Affiliations
          Department of Orthopaedic Surgery U, Medical Department P (Division of Nephrology), and Department of Radiology X, Rigshospitalet, University Hospital, and the Cyclotron Department, Niels Bohr Institute, Copenhagen
          Article
          181375 Nephron 1978;21:86–94
          10.1159/000181375
          353575
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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