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      Assessment of Geant4 Prompt-Gamma Emission Yields in the Context of Proton Therapy Monitoring

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          Abstract

          Monte Carlo tools have been long used to assist the research and development of solutions for proton therapy monitoring. The present work focuses on the prompt-gamma emission yields by comparing experimental data with the outcomes of the current version of Geant4 using all applicable proton inelastic models. For the case in study and using the binary cascade model, it was found that Geant4 overestimates the prompt-gamma emission yields by 40.2 ± 0.3%, even though it predicts the prompt-gamma profile length of the experimental profile accurately. In addition, the default implementations of all proton inelastic models show an overestimation in the number of prompt gammas emitted. Finally, a set of built-in options and physically sound Geant4 source code changes have been tested in order to try to improve the discrepancy observed. A satisfactory agreement was found when using the QMD model with a wave packet width equal to 1.3 fm 2.

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          Review of Particle Physics

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            ROOT — An object oriented data analysis framework

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              In vivo proton range verification: a review.

              Protons are an interesting modality for radiotherapy because of their well defined range and favourable depth dose characteristics. On the other hand, these same characteristics lead to added uncertainties in their delivery. This is particularly the case at the distal end of proton dose distributions, where the dose gradient can be extremely steep. In practice however, this gradient is rarely used to spare critical normal tissues due to such worries about its exact position in the patient. Reasons for this uncertainty are inaccuracies and non-uniqueness of the calibration from CT Hounsfield units to proton stopping powers, imaging artefacts (e.g. due to metal implants) and anatomical changes of the patient during treatment. In order to improve the precision of proton therapy therefore, it would be extremely desirable to verify proton range in vivo, either prior to, during, or after therapy. In this review, we describe and compare state-of-the art in vivo proton range verification methods currently being proposed, developed or clinically implemented.
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                Author and article information

                Contributors
                Journal
                Front Oncol
                Front Oncol
                Front. Oncol.
                Frontiers in Oncology
                Frontiers Media S.A.
                2234-943X
                28 January 2016
                2016
                : 6
                : 10
                Affiliations
                [1] 1CNRS/IN2P3 UMR 5822, IPNL, Université de Lyon, Université Lyon 1 , Villeurbanne, France
                [2] 2CREATIS, CNRS UMR 5220, INSERM U1044, INSA-Lyon, Centre Léon Bérard, Université de Lyon, Université Lyon 1 , Lyon, France
                Author notes

                Edited by: Francis A. Cucinotta, University of Nevada Las Vegas, USA

                Reviewed by: Joshua Silverman, New York University Medical Center, USA; Yu Kuang, University of Nevada Las Vegas, USA

                *Correspondence: Etienne Testa, e.testa@ 123456ipnl.in2p3.fr

                Present address: Marco Pinto, Ludwig Maximilians University, Munich, Germany

                Specialty section: This article was submitted to Radiation Oncology, a section of the journal Frontiers in Oncology

                Article
                10.3389/fonc.2016.00010
                4729887
                26858937
                5734b787-ecce-476e-88fb-e939e77a77ed
                Copyright © 2016 Pinto, Dauvergne, Freud, Krimmer, Létang and Testa.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 30 September 2015
                : 11 January 2016
                Page count
                Figures: 7, Tables: 3, Equations: 0, References: 25, Pages: 7, Words: 4987
                Funding
                Funded by: European Commission 10.13039/501100000780
                Award ID: 264552, 241851
                Funded by: Agence Nationale de la Recherche 10.13039/501100001665
                Award ID: ANR-11-LABX-0063, ANR-11-IDEX-0007, ANR-11-INBS-0007
                Categories
                Oncology
                Original Research

                Oncology & Radiotherapy
                proton therapy,hadrontherapy,prompt gammas,geant4,online monitoring,in-beam monitoring,collimated camera,nuclear fragmentation models

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