Objective To investigate the pathological types and features of skin in HIV-infected patients with skin damage, in order to provide a basis for the antiretroviral therapy of acquired immunodeficiency syndrome in future.
Methods The tissues of skin were obtained from HIV-infected patients with skin damage for pathological examination under sterile conditions. The pathological results were observed by light microscope after Hematoxylin-Eosin(HE), acid-fast, periodic acid-Schiff (PAS), and digested-PAS (D-PAS) staining. The pathological characteristics and histopathological features of the skin tissue were described and analyzed.
Results Among the 82 HIV-infected patients with skin damage, the infectious skin diseases were found in 32 patients (39.02%), the inflammatory skin disease were found in 36 patients(43.90%), and the skin tumors were found in 14 patients(17.07%). The pathological findings included Talaromycosis (14 patients), psoriasis (10 patients), eczema (9 patients), Kaposi sarcoma (12 cases). In addition, the frequency of talaromycosis was higher in patients with lower CD4+T lymphocyte count( P=0.003).
Conclusions The main cause of skin damage in HIV-infected patients is the infection of Marneffei basilium, and most of them occur in patients with low CD4 +T lymphocyte count, the inflammation is mainly psoriasis, the most common skin tumor is Kaposi sarcoma. Therefore, we need to strengthen the diagnosis and treatment of various skin diseases.
摘要: 目的 探讨伴发皮肤损害的HIV/AIDS患者的皮肤病理类型及其特点,为艾滋病的诊断和治疗提供依据。 方法无菌条件取伴有皮肤损害的HIV/AIDS患者的皮肤组织进行病理学检查,通过HE、抗酸、过碘酸雪夫(PAS)和淀粉酶消化后过碘酸雪夫(D-PAS)染色,光学显微镜下观察形态学,描述组织病理特点,并对病理结果进行统计学分析。 结果82例HIV/AIDS患者的皮肤组织病理学检查表现为感染性皮肤病32例(占39.02%),炎症性皮肤病36例(占43.90%),皮肤肿瘤14例(占17.07%)。其中马尔尼菲篮状菌病14例,银屑病10例,湿疹9例,卡波西肉瘤12例。马尔尼菲篮状菌随着CD4+T淋巴细胞计数的减少,感染率升高( P=0.003)。 结论HIV/AIDS患者皮肤损害的原因感染性主要为马尔尼菲篮状菌感染,且多数发生在CD4+T淋巴细胞计数低下的患者,炎症性主要为银屑病,最常见的皮肤肿瘤为卡波西肉瘤,临床上需要加强对HIV/AIDS患者伴发各种皮肤病的诊断和治疗。