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      Pathology of skin in acquired immune deficiency syndrome patients with skin damage

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          Abstract

          Objective To investigate the pathological types and features of skin in HIV-infected patients with skin damage, in order to provide a basis for the antiretroviral therapy of acquired immunodeficiency syndrome in future.

          Methods The tissues of skin were obtained from HIV-infected patients with skin damage for pathological examination under sterile conditions. The pathological results were observed by light microscope after Hematoxylin-Eosin(HE), acid-fast, periodic acid-Schiff (PAS), and digested-PAS (D-PAS) staining. The pathological characteristics and histopathological features of the skin tissue were described and analyzed.

          Results Among the 82 HIV-infected patients with skin damage, the infectious skin diseases were found in 32 patients (39.02%), the inflammatory skin disease were found in 36 patients(43.90%), and the skin tumors were found in 14 patients(17.07%). The pathological findings included Talaromycosis (14 patients), psoriasis (10 patients), eczema (9 patients), Kaposi sarcoma (12 cases). In addition, the frequency of talaromycosis was higher in patients with lower CD4+T lymphocyte count( P=0.003).

          Conclusions The main cause of skin damage in HIV-infected patients is the infection of Marneffei basilium, and most of them occur in patients with low CD4 +T lymphocyte count, the inflammation is mainly psoriasis, the most common skin tumor is Kaposi sarcoma. Therefore, we need to strengthen the diagnosis and treatment of various skin diseases.

          Abstract

          摘要: 目的 探讨伴发皮肤损害的HIV/AIDS患者的皮肤病理类型及其特点,为艾滋病的诊断和治疗提供依据。 方法无菌条件取伴有皮肤损害的HIV/AIDS患者的皮肤组织进行病理学检查,通过HE、抗酸、过碘酸雪夫(PAS)和淀粉酶消化后过碘酸雪夫(D-PAS)染色,光学显微镜下观察形态学,描述组织病理特点,并对病理结果进行统计学分析。 结果82例HIV/AIDS患者的皮肤组织病理学检查表现为感染性皮肤病32例(占39.02%),炎症性皮肤病36例(占43.90%),皮肤肿瘤14例(占17.07%)。其中马尔尼菲篮状菌病14例,银屑病10例,湿疹9例,卡波西肉瘤12例。马尔尼菲篮状菌随着CD4+T淋巴细胞计数的减少,感染率升高( P=0.003)。 结论HIV/AIDS患者皮肤损害的原因感染性主要为马尔尼菲篮状菌感染,且多数发生在CD4+T淋巴细胞计数低下的患者,炎症性主要为银屑病,最常见的皮肤肿瘤为卡波西肉瘤,临床上需要加强对HIV/AIDS患者伴发各种皮肤病的诊断和治疗。

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          Author and article information

          Journal
          CTM
          China Tropical Medicine
          China Tropical Medicine (China )
          1009-9727
          01 January 2020
          01 March 2020
          : 20
          : 1
          : 77-80
          Affiliations
          1The Fourth People’s Hospital of Nanning, Nanning, Guangxi 530023, China
          2The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China
          Author notes
          Corresponding author: WU Nianning, E-mail: Wunianning62@ 123456163.com
          Article
          j.cnki.46-1064/r.2020.01.18
          10.13604/j.cnki.46-1064/r.2020.01.18
          © 2020 Editorial Department of China Tropical Medicine

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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