Objective To investigate the pathological types and features of skin in HIV-infected patients with skin damage, in order to provide a basis for the antiretroviral therapy of acquired immunodeficiency syndrome in future.
Methods The tissues of skin were obtained from HIV-infected patients with skin damage for pathological examination under sterile conditions. The pathological results were observed by light microscope after Hematoxylin-Eosin(HE), acid-fast, periodic acid-Schiff (PAS), and digested-PAS (D-PAS) staining. The pathological characteristics and histopathological features of the skin tissue were described and analyzed.
Results Among the 82 HIV-infected patients with skin damage, the infectious skin diseases were found in 32 patients (39.02%), the inflammatory skin disease were found in 36 patients(43.90%), and the skin tumors were found in 14 patients(17.07%). The pathological findings included Talaromycosis (14 patients), psoriasis (10 patients), eczema (9 patients), Kaposi sarcoma (12 cases). In addition, the frequency of talaromycosis was higher in patients with lower CD4+T lymphocyte count( P=0.003).
Conclusions The main cause of skin damage in HIV-infected patients is the infection of Marneffei basilium, and most of them occur in patients with low CD4 +T lymphocyte count, the inflammation is mainly psoriasis, the most common skin tumor is Kaposi sarcoma. Therefore, we need to strengthen the diagnosis and treatment of various skin diseases.
摘要： 目的 探讨伴发皮肤损害的HIV/AIDS患者的皮肤病理类型及其特点，为艾滋病的诊断和治疗提供依据。 方法无菌条件取伴有皮肤损害的HIV/AIDS患者的皮肤组织进行病理学检查，通过HE、抗酸、过碘酸雪夫(PAS)和淀粉酶消化后过碘酸雪夫(D-PAS)染色，光学显微镜下观察形态学，描述组织病理特点，并对病理结果进行统计学分析。 结果82例HIV/AIDS患者的皮肤组织病理学检查表现为感染性皮肤病32例（占39.02%),炎症性皮肤病36例（占43.90%),皮肤肿瘤14例(占17.07%)。其中马尔尼菲篮状菌病14例，银屑病10例，湿疹9例，卡波西肉瘤12例。马尔尼菲篮状菌随着CD4+T淋巴细胞计数的减少，感染率升高( P=0.003)。 结论HIV/AIDS患者皮肤损害的原因感染性主要为马尔尼菲篮状菌感染，且多数发生在CD4+T淋巴细胞计数低下的患者，炎症性主要为银屑病，最常见的皮肤肿瘤为卡波西肉瘤，临床上需要加强对HIV/AIDS患者伴发各种皮肤病的诊断和治疗。