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In vitro and in vivo studies of an aqueous extract of Matricaria recutita (German chamomile) on the radiolabeling of blood constituents, on the morphology of red blood cells and on the biodistribution of the radiopharmaceutical sodium pertechnetate

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      Abstract

      Background:

      Natural products might alter the labeling of blood constituents with technetium-99m ( 99mTc) and these results may be correlated with modifications of the shape of the red blood cells (RBC). The biodistribution of radiopharmaceuticals can be also altered.

      Objective:

      This investigation aimed to determine biological effects of an aqueous extract of chamomile (CE).

      Materials and Methods:

      To study the effect of the CE on the labeling of blood constituents with 99mTc, in vitro and in vivo assays were performed. The effect of the CE on the morphology of RBC was observed under light microscope. The images were acquired, processed, and the perimeter/area ratio of the RBC determined. To analyze the effect of the CE on biodistribution of the sodium pertechnetate (Na 99mTcO 4) in Wistar rats, these animals were treated or not with a CE. Na 99mTcO 4 was injected, the rats were sacrificed, the organs were removed, weighted and percentage of radioactivity/gram calculated.

      Result:

      In the in vitro experiment, the radioactivity on blood cells compartment and on insoluble fractions of plasma was diminished. The shape and the perimeter/area ratio of the RBC were altered in in vitro assays. An increase of the percentage of radioactivity of Na 99mTcO 4 was observed in stomach after in vivo treatment.

      Conclusion:

      These results could be due to substances of the CE or by the products of the metabolism of this extract in the animal organism. These findings are examples of drug interaction with a radiopharmaceutical, which could lead to misdiagnosis in clinical practice with unexpected consequences.

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      Most cited references 32

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      Fundamentals of Nuclear Pharmacy

       GB SAHA,  GB Saha,  B Saha (2004)
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        Chamomile (Matricaria chamomilla L.): An overview

        Chamomile (Matricaria chamomilla L.) is a well-known medicinal plant species from the Asteraceae family often referred to as the “star among medicinal species.” Nowadays it is a highly favored and much used medicinal plant in folk and traditional medicine. Its multitherapeutic, cosmetic, and nutritional values have been established through years of traditional and scientific use and research. Chamomile has an established domestic (Indian) and international market, which is increasing day by day. The plant available in the market many a times is adulterated and substituted by close relatives of chamomile. This article briefly reviews the medicinal uses along with botany and cultivation techniques. Since chamomile is a rich source of natural products, details on chemical constituents of essential oil and plant parts as well as their pharmacological properties are included. Furthermore, particular emphasis is given to the biochemistry, biotechnology, market demand, and trade of the plant. This is an attempt to compile and document information on different aspects of chamomile and highlight the need for research and development.
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          Chamomile: A herbal medicine of the past with bright future.

          Chamomile is one of the most ancient medicinal herbs known to mankind. It is a member of Asteraceae/Compositae family and represented by two common varieties viz. German Chamomile (Chamomilla recutita) and Roman Chamomile (Chamaemelum nobile). The dried flowers of chamomile contain many terpenoids and flavonoids contributing to its medicinal properties. Chamomile preparations are commonly used for many human ailments such as hay fever, inflammation, muscle spasms, menstrual disorders, insomnia, ulcers, wounds, gastrointestinal disorders, rheumatic pain, and hemorrhoids. Essential oils of chamomile are used extensively in cosmetics and aromatherapy. Many different preparations of chamomile have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day. In this review we describe the use of chamomile in traditional medicine with regard to evaluating its curative and preventive properties, highlight recent findings for its development as a therapeutic agent promoting human health.
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            Author and article information

            Affiliations
            [1 ] Laboratório de Radiofarmácia Experimental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, RJ, Brasil
            [2 ] Programa de Pós-Graduação em Biologia Humana e Experimental, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, RJ, Brasil
            [3 ] Laboratório de Ultraestrutura e Biologia Tecidual, Departamento de Histologia e Embriologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, RJ, Brasil
            [4 ] Laboratório de Fisiologia da Nutrição e Desenvolvimento, Departamento de Fisiologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, RJ, Brasil
            Author notes
            Address for correspondence: Dr. Angélica Beatriz Garcia-Pinto, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, Laboratório de Radiofarmácia Experimental, Av. 28 de Setembro, 87, 20551-030, Rio de Janeiro, RJ, Brasil. E-mail: abpgarcia@ 123456gmail.com.br
            Journal
            Pharmacogn Mag
            Pharmacogn Mag
            PM
            Pharmacognosy Magazine
            Medknow Publications & Media Pvt Ltd (India )
            0973-1296
            0976-4062
            Oct-Dec 2013
            : 9
            : Suppl 1
            : S49-S56
            3798140 PM-9-49 10.4103/0973-1296.117867
            Copyright: © Pharmacognosy Magazine

            This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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