Novel 99mTc-Radiolabeled Anionic Linear Globular PEG-Based Dendrimer-Chlorambucil: Non-Invasive Method for In-Vivo Biodistribution.

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Abstract

Chlorambucil (CBL) is an alkylating agent, which widely use in the treatment of various types of tumors. The main purpose of this study is to evaluate the in-vivo biodistribution of CBL conjugated to the anionic dendrimer, which has a great ability to labeled with 99mTc through binding to carboxylate terminate groups. Whole body scans were used to analyze the percentage of the injected dose in different times. Radiochemical purity (RCP) and in-vivo biodistribution were also calculated with the SPECT/CT instrument. Our study proposes a new method for RCP determination and shows that this carrier is a promising agent to complex with the 99mTc and biological assessment.

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Journal

Journal ID (iso-abbrev): Drug Res (Stuttg)

Title: Drug research

Publisher: Georg Thieme Verlag KG

ISSN (Electronic): 2194-9387

ISSN (Print): 2194-9379

Publication date (Electronic): Mar 2017

Volume: 67

Issue: 3

Affiliations

[1 ] Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran.

[2 ] Department of Nuclear Medicine, Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Article

DOI: 10.1055/s-0042-118448

PubMed ID: 27992934

SO-VID: ae65a068-e733-4fe7-a0a9-e4ab49324201

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