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      Tolerance has its limits: how the thymus copes with infection.

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          Abstract

          The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.

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          Author and article information

          Journal
          Trends Immunol.
          Trends in immunology
          1471-4981
          1471-4906
          Oct 2013
          : 34
          : 10
          Affiliations
          [1 ] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
          Article
          S1471-4906(13)00094-X NIHMS506826
          10.1016/j.it.2013.06.004
          3879077
          23871487
          Copyright © 2013 Elsevier Ltd. All rights reserved.

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