Curcumin anti‐tumor effects on endometrial cancer with focus on its molecular targets

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Abstract

Curcumin is extracted from turmeric and shows a variety of properties that make it a useful agent for treating diseases and targeting different biological mechanisms, including apoptosis, angiogenesis, inflammation, and oxidative stress. This phenolic compound is safe even at high doses. However, it has poor bioavailability. The incidence rates of endometrial cancer (EC) that is one of the most prevalent gynecological malignancies is increasing. Meanwhile, the onset age of EC has been decreased in past few years. Besides, EC does not show a convenient prognosis, particularly at advanced stages. Based on this information, discovering new approaches or enhancing the available ones is required to provide better care for EC patients. In this review, we cover studies concerned with the anti-tumor effects of curcumin on EC. We focus on molecular mechanisms that are targeted by curcumin treatment in different processes of cancer development and progression, such as apoptosis, inflammation, and migration. Furthermore, we present the role of curcumin in targeting some microRNAs (miRNAs) that may play a role in EC.

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Most cited references 78

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Apoptosis: a review of programmed cell death.

Susan A. Elmore (2007)

The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. The ability to modulate the life or death of a cell is recognized for its immense therapeutic potential. Therefore, research continues to focus on the elucidation and analysis of the cell cycle machinery and signaling pathways that control cell cycle arrest and apoptosis. To that end, the field of apoptosis research has been moving forward at an alarmingly rapid rate. Although many of the key apoptotic proteins have been identified, the molecular mechanisms of action or inaction of these proteins remain to be elucidated. The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptosis in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptosis.

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci … (2016)

Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged cells, such as those resulting from DNA damage or during development. Apoptosis can be triggered by signals from within the cell, such as genotoxic stress, or by extrinsic signals, such as the binding of ligands to cell surface death receptors. Deregulation in apoptotic cell death machinery is an hallmark of cancer. Apoptosis alteration is responsible not only for tumor development and progression but also for tumor resistance to therapies. Most anticancer drugs currently used in clinical oncology exploit the intact apoptotic signaling pathways to trigger cancer cell death. Thus, defects in the death pathways may result in drug resistance so limiting the efficacy of therapies. Therefore, a better understanding of the apoptotic cell death signaling pathways may improve the efficacy of cancer therapy and bypass resistance. This review will highlight the role of the fundamental regulators of apoptosis and how their deregulation, including activation of anti-apoptotic factors (i.e., Bcl-2, Bcl-xL, etc) or inactivation of pro-apoptotic factors (i.e., p53 pathway) ends up in cancer cell resistance to therapies. In addition, therapeutic strategies aimed at modulating apoptotic activity are briefly discussed.

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Multiple biological activities of curcumin: a short review.

Radha K Maheshwari, Anoop Singh, Jaya P Gaddipati … (2006)

Turmeric (Curcuma longa rhizomes), commonly used as a spice is well documented for its medicinal properties in Indian and Chinese systems of medicine. It has been widely used for the treatment of several diseases. Epidemiological observations, though inconclusive, are suggestive that turmeric consumption may reduce the risk of some form of cancers and render other protective biological effects in humans. These biological effects of turmeric have been attributed to its constituent curcumin that has been widely studied for its anti-inflammatory, anti-angiogenic, anti-oxidant, wound healing and anti-cancer effects. As a result of extensive epidemiological, clinical, and animal studies several molecular mechanisms are emerging that elucidate multiple biological effects of curcumin. This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin.

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Author and article information

Contributors

Fahime Jahanbakhshi: Fahime_jahanbakhshi@yahoo.com

Parisa Maleki Dana: prs.maleki@yahoo.com

Bita Badehnoosh: b_badehnoosh@yahoo.com

Bahman Yousefi: bahmanusefi@gmail.com

Mohammad Ali Mansournia: mansournia_ma@yahoo.com

Moghadeseh Jahanshahi: ebiebrahimpishy@gmail.com

Zatollah Asemi: Asemi_r@yahoo.com

Jamal Halajzadeh:

ORCID: http://orcid.org/0000-0003-0696-9229

jamal.hallaj@yahoo.com

Journal

Journal ID (nlm-ta): Cancer Cell Int

Journal ID (iso-abbrev): Cancer Cell Int

Title: Cancer Cell International

Publisher: BioMed Central (London )

ISSN (Electronic): 1475-2867

Publication date (Electronic): 18 February 2021

Publication date PMC-release: 18 February 2021

Publication date Collection: 2021

Volume: 21

Electronic Location Identifier: 120

Affiliations

[1 ]GRID grid.411600.2, Department of Gynecology and Obstetrics, School of Medicine, , Shahid Beheshti University of Medical Sciences, ; Tehran, Iran

[2 ]GRID grid.444768.d, ISNI 0000 0004 0612 1049, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, , Kashan University of Medical Sciences, ; Kashan, Islamic Republic of Iran

[3 ]GRID grid.411705.6, ISNI 0000 0001 0166 0922, Department of Gynecology and Obstetrics, Dietary Supplements and Probiotic Research Center, , Alborz University of Medical Sciences, ; Karaj, Iran

[4 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Molecular Medicine Research Center, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[5 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[6 ]GRID grid.411705.6, ISNI 0000 0001 0166 0922, Department of Epidemiology and Biostatistics, School of Public Health, , Tehran University of Medical Sciences, ; Tehran, Iran

[7 ]GRID grid.411747.0, ISNI 0000 0004 0418 0096, Clinical Research Development Center (CRDC), Sayad Shirazi Hospital, , Golestan University of Medical Sciences, ; Gorgan, Iran

[8 ]GRID grid.449862.5, Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, , Maragheh University of Medical Sciences, ; Maragheh, Iran

Author information

Jamal Halajzadeh http://orcid.org/0000-0003-0696-9229

Article

Publisher ID: 1832

DOI: 10.1186/s12935-021-01832-z

PMC ID: 7891161

PubMed ID: 33602218

SO-VID: 5816a99e-05de-4eba-86f5-2a7444328df0

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 19 December 2019

Date accepted : 10 February 2021

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ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: curcumin,endometrial cancer,apoptosis,migration,microrna,inflammation

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ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: curcumin, endometrial cancer, apoptosis, migration, microrna, inflammation

Curcumin anti‐tumor effects on endometrial cancer with focus on its molecular targets

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Karger: Oncology

Most cited references 78

Apoptosis: a review of programmed cell death.

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Multiple biological activities of curcumin: a short review.

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