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      Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning.

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          Abstract

          Members of the fibroblast growth factor (FGF) family of growth factors are key regulators of limb skeletal patterning and growth. Abnormal expression of FGFs or mutations in their receptors (fgfrs) result in skeletal disorders. Here we show that changes in the expression of fgfrs are intrinsic properties of differentiating cartilage. In mesenchymal micromass cultures differentiating into cartilage, as in ovo, fgfr 1 mRNA was found predominantly in undifferentiated, proliferating mesenchyme, fgfr 2 in precartilage cell aggregates, and fgfr 3 in differentiating cartilage nodules. Thus, our data suggest that switches in the expression of fgfr 1, 2, and 3 mRNAs are associated with phases of cartilage patterning both in vitro and in ovo, and mark distinct stages in the development of the limb skeleton.

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          Author and article information

          Journal
          Dev. Dyn.
          Developmental dynamics : an official publication of the American Association of Anatomists
          Wiley
          1058-8388
          1058-8388
          Dec 1995
          : 204
          : 4
          Affiliations
          [1 ] Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA.
          Article
          10.1002/aja.1002040410
          8601037
          5824db2e-127e-4bcc-908d-2d7b7932bf6d

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