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      Effect of Recombinant Human Erythropoietin Treatment in Uremic Patients on Oxygen Affinity of Hemoglobin

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          Abstract

          Anemia of chronic renal failure is associated with a reduced affinity of hemoglobin for oxygen (Hb-O<sub>2</sub> affinity). It has been reported that the correction of renal anemia by recombinant human erythropoietin (rhuEPO) treatment could be associated paradoxically with a further decrease in Hb-O<sub>2</sub> affinity. We investigated changes in the compensatory mechanisms of chronic renal anemia during 25 weeks of rhuEPO treatment, in 19 chronic hemodialyzed (HD) patients. There was no significant variation of mean standard P<sub>50</sub> (P<sub>50</sub>std). Average 2,3-diphos-phoglycerate (DPG) increased after 13 weeks and remained stable. The large interindividual variations prompted us to study ΔP<sub>50</sub>std and ΔHb. We demonstrated a negative correlation between ΔP<sub>50</sub>std and ΔHb. Thus, P<sub>50</sub>std increased in patients who did not immediately correct their anemia and decreased in patients whose Hb values rose. These data showed that the major factor influencing variations of Hb-O<sub>2</sub> affinity in chronic HD patients treated by rhuEPO is the variation of Hb concentrations. In our study, it was demonstrated that the most important rise in P<sub>50</sub>std and 2,3-DPG occurred in patients who were late responders to rhuEPO.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1994
          1994
          16 December 2008
          : 66
          : 2
          : 147-152
          Affiliations
          aService de Néphrologie, et bLaboratoire d’Explorations Fonctionnelles Respiratoires, Hôpital Sainte Marguerite; cLaboratoire de Biophysique, Faculté de Pharmacie, Marseille, France; dUniversity of Rostock, FRG
          Article
          187792 Nephron 1994;66:147–152
          10.1159/000187792
          8139733
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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