Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial).

Cruz-Chamorro, Ivan; Álvarez-Sánchez, Nuria; Álvarez-Ríos, Ana Isabel; Santos-Sánchez, Guillermo; Pedroche, Justo; Millán, Francisco; Carrera Sánchez, Cecilio; Fernández-Pachón, María Soledad; Millán-Linares, María Carmen; Martínez-López, Alicia; Lardone, Patricia Judith; Bejarano, Ignacio; Guerrero, Juan Miguel; Carrillo-Vico, Antonio

doi:10.1002/mnfr.202100139

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Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial).

Author(s): Ivan Cruz-Chamorro ¹ ^, ² , Nuria Álvarez-Sánchez ¹ , Ana Isabel Álvarez-Ríos ³ , Guillermo Santos-Sánchez ¹ ^, ² , Justo Pedroche ⁴ , Francisco Millán ⁴ , Cecilio Carrera Sánchez ⁵ , María Soledad Fernández-Pachón ⁶ , María Carmen Millán-Linares ⁴ ^, ⁷ , Alicia Martínez-López ¹ ^, ² , Patricia Judith Lardone ¹ ^, ² , Ignacio Bejarano ¹ ^, ² , Juan Miguel Guerrero ¹ ^, ² ^, ³ , Antonio Carrillo-Vico ¹ ^, ²

Publication date (Electronic): July 2021

Journal: Molecular nutrition & food research

Publisher: Wiley

Keywords: cholesterol, hydrolysate, inflammation, lupine, oxidative stress

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Abstract

We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects.

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Journal

Journal ID (iso-abbrev): Mol Nutr Food Res

Title: Molecular nutrition & food research

Publisher: Wiley

ISSN (Electronic): 1613-4133

ISSN (Print): 1613-4125

Publication date (Electronic): July 2021

Volume: 65

Issue: 14

Affiliations

[1 ] Instituto de Biomedicina de Sevilla, IBiS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Seville, Spain.

[2 ] Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla, Seville, Spain.

[3 ] Departamento de Bioquímica Clínica, Unidad de Gestión, de Laboratorios, Hospital Universitario Virgen del Rocío, Seville, Spain.

[4 ] Plant Protein Group, Instituto de la Grasa, CSIC, Ctra. Utrera Km 1, Seville, 41013, Spain.

[5 ] Departamento de Ingeniería Química, Facultad de Química, Universidad de Sevilla, Seville, Spain.

[6 ] Área de Nutrición y Bromatología, Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Ctra. Utrera Km 1, Seville, 41013, Spain.

[7 ] Cell Biology Unit, Instituto de la Grasa, CSIC, Ctra. Utrera Km 1, Seville, 41013, Spain.