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      Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties.

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          Abstract

          Crocin, a water-soluble carotenoid in saffron, is a highly bioactive compound with limited use due to instability to pH variations, heat and oxidative stress, rapid absorption and low bioavailability. In this study, chitosan-alginate nanoparticles, considered as a new vehicle for crocin to improve properties in terms of antioxidant activity, bioavailability and anticancer activity. The swelling of crocin loaded nanoparticles was pH-dependent so that the highest swelling ratio (16g/g) was observed in acidic condition (pH=1.2) after 24h. The antioxidant activity of the crocin loaded nanoparticles was the same effective as pure crocin on DPPH free radical scavenging and ferric reducing ability of plasma (FRAP). In vitro crocin release profile from composite nanoparticles was investigated under simulated physiological conditions during incubation time. The experimental reports collected in this study strongly indicate that nanoparticles loaded with crocin could be the prospective candidates for the future anti-cancer therapeutics that deserve additional investigations.

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          Author and article information

          Journal
          Int. J. Biol. Macromol.
          International journal of biological macromolecules
          Elsevier BV
          1879-0003
          0141-8130
          Jun 2017
          : 99
          Affiliations
          [1 ] Department of Food science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran; Department of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.
          [2 ] Department of Microbial Biotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran. Electronic address: hashemim@abrii.ac.ir.
          [3 ] Biotechnology Group, Department of Chemical Engineering, Tarbiat Modarres University, Tehran, Iran.
          [4 ] Department of Food science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran.
          Article
          S0141-8130(16)32516-8
          10.1016/j.ijbiomac.2017.02.095
          28254570
          5a070703-55d4-4ca7-b4e2-b272aa847815
          History

          Anticancer activity,Antioxidant activity,Controlled release,Crocin,Nanoparticles

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