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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study
Brendon P Scicluna ,
Lonneke A van Vught ,
Aeilko H Zwinderman ,
Maryse A Wiewel ,
Emma E Davenport ,
Katie L Burnham ,
Peter Nürnberg ,
Marcus J Schultz ,
Janneke Horn ,
Olaf L Cremer ,
Marc J Bonten ,
Charles J Hinds ,
Hector R Wong ,
Julian C Knight ,
Tom van der Poll ,
Friso M. de Beer ,
Lieuwe D.J. Bos ,
Jos F. Frencken ,
Maria E. Koster-Brouwer ,
Kirsten van de Groep ,
Diana M. Verboom ,
Gerie J. Glas ,
Roosmarijn T.M. van Hooijdonk ,
Arie J. Hoogendijk ,
Mischa A. Huson ,
Peter M. Klein Klouwenberg ,
David S.Y. Ong ,
Laura R.A. Schouten ,
Marleen Straat ,
Esther Witteveen ,
Luuk Wieske
October 2017
October 2017
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Abstract
Host responses during sepsis are highly heterogeneous, which hampers the identification
of patients at high risk of mortality and their selection for targeted therapies.
In this study, we aimed to identify biologically relevant molecular endotypes in patients
with sepsis.