Chronic renal failure is associated with distal symmetrical axonal neuropathy. We report a 50-year-old man who suffered from chronic renal failure due to benign enlargement of the prostate. He presented with fever and rapidly developing pure motor neuropathy. The nerve conduction velocity was slow and the F response delayed, suggestive of demyelinating neuropathy. A sural nerve biopsy specimen was also consistent with demyelination and axonal changes. This patient improved significantly following intermittent catheterization and a short course of norfloxacin. Renal failure may be associated with reversible motor neuropathy.