This paper aims to examine characteristics of e-bike fatal crashes on urban highways in China. Crash data were retrieved from the three-year crash reports (2010–2012) of Taixing City. Descriptive analysis was conducted to examine characteristics of e-bike riders, drivers, and crashes. The important findings include the following: (1) most fatal crashes were related to e-bike riders’ aberrant driving behaviors, including driving in motorized lanes, red-light running, driving against the direction of traffic, inattentive driving, and drunk driving; (2) e-bike riders with lower educational background tended to perform illegal or inattentive driving behaviors in fatal crashes; (3) most drivers were not found to commit any faults and very few drivers were found to commit drunk driving offences; (4) most nighttime fatal crashes were related to absence of street lightings; (5) heavy good vehicles (HGVs) and small passenger cars were the two vehicle types that were mostly involved in the e-bike fatal crashes. This study provides useful information that can help traffic engineers better understand e-bike safety in China and develop safety countermeasures.