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      Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.

      Nature immunology

      Adoptive Transfer, Animals, CD8-Positive T-Lymphocytes, cytology, immunology, Cell Division, Cell Line, Homeostasis, Immunologic Memory, Interleukin-7, genetics, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Proto-Oncogene Proteins c-bcl-2, metabolism, Radiation Tolerance, Receptors, Interleukin-7

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          Abstract

          The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells. We found that IL-7 was required for homeostatic expansion of naïve CD8+ and CD4+ T cells in lymphopenic hosts and for CD8+ T cell survival in normal hosts. In contrast, IL-7 was not necessary for growth of CD8+ T cells in response to a virus infection but was critical for generating T cell memory. Up-regulation of Bcl-2 in the absence of IL-7 signaling was impaired after activation in vivo. Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis.

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          Journal
          11062503
          10.1038/80868

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