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      Physical activity guidelines and cardiovascular risk in children: a cross sectional analysis to determine whether 60 minutes is enough

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          Abstract

          Background

          Physical activity reduces cardiovascular mortality and morbidity. The World Health Organisation (WHO) recommends children engage in 60 min daily moderate-to-vigorous physical activity (MVPA). The effect of compliance with this recommendation on childhood cardiovascular risk has not been empirically tested. To evaluate whether achieving recommendations results in reduced composite-cardiovascular risk score (CCVR) in children, and to examine if vigorous PA (VPA) has independent risk-reduction effects.

          Methods

          PA was measured using accelerometry in 182 children (9–11 years). Subjects were grouped according to achievement of 60 min daily MVPA (active) or not (inactive). CCVR was calculated (sum of z-scores: DXA body fat %, blood pressure, VO 2peak, flow mediated dilation, left ventricular diastolic function; CVR score ≥1SD indicated ‘higher risk’). The cohort was further split into quintiles for VPA and odds ratios (OR) calculated for each quintile.

          Results

          Active children (92 (53 boys)) undertook more MVPA (38 ± 11 min, P < 0.001), had greater VO 2peak (4.5 ± 0.8 ml/kg/min P < 0.001), and lower fat % (3.9 ± 1.1 %, P < 0.001) than inactive. No difference were observed between active and inactive for CCVR or OR ( P > 0.05). CCVR in the lowest VPA quintile was significantly greater than the highest quintile (3.9 ± 0.6, P < 0.05), and the OR was 4.7 times higher.

          Conclusion

          Achievement of current guidelines has positive effects on body composition and cardiorespiratory fitness, but not CCVR. Vigorous physical activity appears to have beneficial effects on CVD risk, independent of moderate PA, implying a more prescriptive approach may be needed for future VPA guidelines.

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          Most cited references17

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          Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms.

          Higher levels of physical activity are associated with fewer cardiovascular disease (CVD) events. Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect. In a prospective study of 27,055 apparently healthy women, we measured baseline levels of hemoglobin A1c, traditional lipids (total, low-density lipoprotein, and high-density lipoprotein cholesterol), novel lipids [lipoprotein(a) and apolipoprotein A1 and B-100], creatinine, homocysteine, and inflammatory/hemostatic biomarkers (high-sensitivity C-reactive protein, fibrinogen, soluble intracellular adhesion molecule-1) and used women's self-reported physical activity, weight, height, hypertension, and diabetes. Mean follow-up was 10.9+/-1.6 years, and 979 incident CVD events occurred. The risk of CVD decreased linearly with higher levels of activity (P for linear trend or = 1500 kcal/wk of 27%, 32%, and 41%, respectively. Differences in known risk factors explained a large proportion (59.0%) of the observed inverse association. When sets of risk factors were examined, inflammatory/hemostatic biomarkers made the largest contribution to lower risk (32.6%), followed by blood pressure (27.1%). Novel lipids contributed less to CVD risk reduction compared with traditional lipids (15.5% and 19.1%, respectively). Smaller contributions were attributed to body mass index (10.1%) and hemoglobin A1c/diabetes (8.9%), whereas homocysteine and creatinine had negligible effects (< 1%). The inverse association between physical activity and CVD risk is mediated in substantial part by known risk factors, particularly inflammatory/hemostatic factors and blood pressure.
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            Global recommendations on physical activity for health

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              Physical activity and cardiovascular risk factors in children.

              A number of recent systematic reviews have resulted in changes in international recommendations for children's participation in physical activity (PA) for health. The World Health Authority (WHO) has recently released new recommendations. The WHO still recommends 60 min of moderate to vigorous physical activity (MVPA), but also emphasises that these minutes should be on top of everyday physical activities. Everyday physical activities total around 30 min of MVPA in the quintile of the least active children, which means that the new recommendations constitute more activity in total compared with earlier recommendations. To summarise evidence justifying new PA recommendation for cardiovascular health in children. The results of recent systematic reviews are discussed and supplemented with relevant literature not included in these reviews. PubMed was searched for the years 2006-2011 for additional topics not sufficiently covered by the reviews. PA was associated with lower blood pressure and a healthier lipid blood profile in children. The association was stronger when a composite risk factor score was analysed, and the associations between physical fitness and cardiovascular disease (CVD) risk factors were even stronger. Muscle strength and endurance exercise each had an effect on blood lipids and insulin sensitivity even if the effect was smaller for muscle strength than for aerobic exercise. New evidence suggests possible effects of PA on C-reactive protein. There is accumulating evidence that PA can have beneficial effects on the risk factors of CVD in children. Public health policy to promote PA in children, especially the most sedentary children, may be a key element to prevent the onset of CVD later in the children's lives.
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                Author and article information

                Contributors
                lottefussenich@hotmail.com
                L.M.Boddy@ljmu.ac.uk
                D.J.Green@ljmu.ac.uk
                L.E.Graves@ljmu.ac.uk
                Lawrence.Foweather@edgehill.ac.uk
                daggerb@hope.ac.uk
                n.mcwhannell@chester.ac.uk
                jaynehenaghan@googlemail.com
                nicky.ridgers@deakin.edu.au
                G.Stratton@swansea.ac.uk
                N.d.hopkins@ljmu.ac.uk , spsnhopk@livjm.ac.uk
                Journal
                BMC Public Health
                BMC Public Health
                BMC Public Health
                BioMed Central (London )
                1471-2458
                22 January 2016
                22 January 2016
                2015
                : 16
                : 67
                Affiliations
                [ ]Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
                [ ]Research Institute for Sport and Exercise Science, Liverpool John Moore’s University, Tom Reilly Building, Byrom Street, Liverpool, L3 2ET UK
                [ ]School of Sports Science, Exercise and Health, The University of Western Australia, Crawley, Perth, WA 6009 Australia
                [ ]School of Health Sciences, Liverpool Hope University, Liverpool, L16 9JD UK
                [ ]Department of Sport and Exercise Science, University of Chester, Chester, CH1 4BJ UK
                [ ]Centre for Physical Activity and Nutrition (C-PAN) Research, Deakin University, 221 Burwood Highway, Burwood, VIC 3175 Australia
                [ ]Applied Sports Technology Exercise and Medicine Research Centre (A-STEM), Swansea University, Swansea, SA2 8PP UK
                Article
                2708
                10.1186/s12889-016-2708-7
                4724140
                26801090
                5e9ed5d7-82b3-4607-ba11-f69bc77282fd
                © Füssenich et al. 2016

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 11 June 2015
                : 8 January 2016
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2016

                Public health
                physical activity guidelines,moderate/vigorous physical activity,clustered cardiovascular risk

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