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      Fibroblast growth factor receptor signaling in kidney and lower urinary tract development

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          Abstract

          Fibroblast growth factor receptors (FGFRs) and FGF ligands are highly expressed in the developing kidney and lower urinary tract. Several classic studies showed many effects of exogenous FGF ligands on embryonic renal tissues in vitro and in vivo. Another older landmark publication showed that mice with a dominant negative Fgfr fragment had severe renal dysplasia. Together these studies revealed the importance of FGFR signaling in kidney and lower urinary tract development. With the advent of modern gene targeting techniques, including conditional knockout approaches, several publications have revealed critical roles for FGFR signaling in many lineages of the kidney and lower urinary tract at different stages of development. FGFR signaling has been shown to be critical for early metanephric mesenchymal patterning, Wolffian duct patterning including induction of the ureteric bud, ureteric bud branching morphogenesis, nephron progenitor survival and nephrogenesis, and bladder mesenchyme patterning. FGFRs pattern these tissues by interacting with many other growth factor signaling pathways. Moreover, the many genetic Fgfr and Fgf animal models have structural defects mimicking numerous congenital anomalies of the kidney and urinary tract seen in humans. Finally, many studies have shown how FGFR signaling is critical for kidney and lower urinary tract patterning in humans.

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          Author and article information

          Journal
          8708728
          1785
          Pediatr Nephrol
          Pediatr. Nephrol.
          Pediatric nephrology (Berlin, Germany)
          0931-041X
          1432-198X
          1 September 2015
          21 August 2015
          June 2016
          01 June 2017
          : 31
          : 6
          : 885-895
          Affiliations
          [1 ]Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
          [2 ]Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
          Author notes
          Corresponding author information: Carlton M. Bates, Rangos Research building, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, batescm@ 123456upmc.edu , Phone: 412-692-9440
          Article
          PMC4761523 PMC4761523 4761523 nihpa717603
          10.1007/s00467-015-3151-1
          4761523
          26293980
          60da00c2-52e7-426d-86b3-839bf0be09b5
          History
          Categories
          Article

          Conditional knockout,Bladder organogenesis,Renal organogenesis,Ureteric bud,Metanephric mesenchyme,Fibroblast growth factors

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