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      Correction: Won-Kyung Cho; et al. Epimedium Koreanum Nakai Displays Broad Spectrum of Antiviral Activity In Vitro and In Vivo by Inducing Cellular Antiviral State. Viruses 2015, 7, 352–377

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          Abstract

          The authors wish to make the following change to their paper [1]. The image showing the immunoblot for p. 38 was not placed correctly in the original Figure 3C [1]. Figure 3 should be replaced with: The authors would like to apologize for any inconvenience caused. The change does not significantly affect the scientific results. The manuscript will be updated and the original will remain available on the article webpage.

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          Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State

          Won-Kyung Cho, Prasanna Weeratunga, Byeong-Hoon Lee … (2015)
          Epimedium koreanum Nakai has been extensively used in traditional Korean and Chinese medicine to treat a variety of diseases. Despite the plant’s known immune modulatory potential and chemical make-up, scientific information on its antiviral properties and mode of action have not been completely investigated. In this study, the broad antiviral spectrum and mode of action of an aqueous extract from Epimedium koreanum Nakai was evaluated in vitro, and moreover, the protective effect against divergent influenza A subtypes was determined in BALB/c mice. An effective dose of Epimedium koreanum Nakaimarkedly reduced the replication of Influenza A Virus (PR8), Vesicular Stomatitis Virus (VSV), Herpes Simplex Virus (HSV) and Newcastle Disease Virus (NDV) in RAW264.7 and HEK293T cells. Mechanically, we found that an aqueous extract from Epimedium koreanum Nakai induced the secretion of type I IFN and pro-inflammatory cytokines and the subsequent stimulation of the antiviral state in cells. Among various components present in the extract, quercetin was confirmed to have striking antiviral properties. The oral administration of Epimedium koreanum Nakai exhibited preventive effects on BALB/c mice against lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3 and H9N2). Therefore, an extract of Epimedium koreanum Nakai and its components play roles as immunomodulators in the innate immune response, and may be potential candidates for prophylactic or therapeutic treatments against diverse viruses in animal and humans.
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            Author and article information

            Journal
            Journal ID (nlm-ta): Viruses
            Journal ID (iso-abbrev): Viruses
            Journal ID (publisher-id): viruses
            Title: Viruses
            Publisher: MDPI
            ISSN (Electronic): 1999-4915
            Publication date (Electronic): 04 June 2018
            Publication date Collection: June 2018
            Publication date PMC-release: 04 June 2018
            Volume: 10
            Issue: 6
            Electronic Location Identifier: 304
            Affiliations
            [1 ]Korean Medicine (KM) Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-764, Korea; wkcho@ 123456kiom.re.kr
            [2 ]College of Veterinary Medicine, Chungnam National University, 220 Gung-Dong, Yuseong-Gu, Daejeon 305-764, Korea; prasannapdn05@ 123456gmail.com (P.W.); byeonghoon_2@ 123456naver.com (B.-H.L.); pjs123a@ 123456naver.com (J.-S.P.); cjkim@ 123456cnu.ac.kr (C.-J.K.)
            Author notes
            [* ]Correspondence: jyma@ 123456kiom.re.kr (J.Y.M.); jongsool@ 123456cnu.ac.kr (J.-S.L.)
            [†]

            The authors contributed equally to this article.

            Author information
            https://orcid.org/0000-0001-5119-0711
            Article
            Publisher ID: viruses-10-00304
            DOI: 10.3390/v10060304
            PMC ID: 6024753
            PubMed ID: 29867067
            SO-VID: 61a8b9dc-5cf9-46b9-a8eb-7aa03e2c649d
            Copyright © © 2018 by the authors.
            License:

            Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

            History
            Date received : 31 May 2018
            Date accepted : 01 June 2018
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            Subject: Correction

            ScienceOpen disciplines: Microbiology & Virology
            Data availability:
            ScienceOpen disciplines: Microbiology & Virology

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