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      Pulmonary Vascular Reactivity in the Spontaneously Hypertensive Rat

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          We examined the pulmonary vascular reactivity of normotensive rats (NR) and spontaneously hypertensive rats (SHR) to acute and chronic pressor stimuli. In rats kept at low altitude (1,520 m), SHRhad a slight degree of right ventricular hypertrophy, but there was no difference between SHRand NR in either right ventricular systolic pressure or pulmonary artery wall thickness. When compared to blood-perfused lungs from low altitude NR, lungs from low altitude SHR were normoresponsive to acute airway hypoxia, hyporesponsive to intra-arterial angiotensin II, and hyperresponsive to intra-arterial prostaglandin F<sub>2</sub><sub>α</sub>. After exposing rats to simulated high altitude (4-6 weeks at 4,270 m) to induce hypoxic pulmonary hypertension, SHRhad a higher right ventricular systolic pressure, a greater degree of right ventricular hypertrophy, and more pulmonary artery medial thickening than did NR. The results indicate that although the pulmonary vasculature of SHRdoes not become hypertensive spontaneously, it might have an increased tendency to develop hypertension when exposed to an appropriate stimulus, i.e., chronic airway hypoxia.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 16
          : 2
          : 61-70
          Cardiovascular Pulmonary Research Laboratory, University of Colorado Medical Center, Denver, Colo.
          158192 Blood Vessels 1979;16:61-70
          © 1979 S. Karger AG, Basel

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          Pages: 10
          Original Paper


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