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      Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

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          Abstract

          Terretonin N ( 1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.

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          Biology and chemistry of endophytes.

          Hua wei Zhang, Yong Song, Ren Tan (2006)
          This review focuses on new endophyte-related findings in biology and ecology, and also summarises the various metabolites isolated from endophytes.
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            Terpene synthases are widely distributed in bacteria.

            Yuuki Yamada, Tomohisa Kuzuyama, Mamoru Komatsu … (2015)
            Odoriferous terpene metabolites of bacterial origin have been known for many years. In genome-sequenced Streptomycetaceae microorganisms, the vast majority produces the degraded sesquiterpene alcohol geosmin. Two minor groups of bacteria do not produce geosmin, with one of these groups instead producing other sesquiterpene alcohols, whereas members of the remaining group do not produce any detectable terpenoid metabolites. Because bacterial terpene synthases typically show no significant overall sequence similarity to any other known fungal or plant terpene synthases and usually exhibit relatively low levels of mutual sequence similarity with other bacterial synthases, simple correlation of protein sequence data with the structure of the cyclized terpene product has been precluded. We have previously described a powerful search method based on the use of hidden Markov models (HMMs) and protein families database (Pfam) search that has allowed the discovery of monoterpene synthases of bacterial origin. Using an enhanced set of HMM parameters generated using a training set of 140 previously identified bacterial terpene synthase sequences, a Pfam search of 8,759,463 predicted bacterial proteins from public databases and in-house draft genome data has now revealed 262 presumptive terpene synthases. The biochemical function of a considerable number of these presumptive terpene synthase genes could be determined by expression in a specially engineered heterologous Streptomyces host and spectroscopic identification of the resulting terpene products. In addition to a wide variety of terpenes that had been previously reported from fungal or plant sources, we have isolated and determined the complete structures of 13 previously unidentified cyclic sesquiterpenes and diterpenes.
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              Marine natural products.

              Murray H. G. Munro, Brent Copp, Peter T. Northcote … (2007)
              This review covers the literature published in 2005 for marine natural products, with 704 citations (493 for the period January to December 2005) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (812 for 2005), together with their relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.
              Article 0 comments Cited 97 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 31 January 2018
                Publication date Collection: February 2018
                Volume: 23
                Issue: 2
                Electronic Location Identifier: 299
                Affiliations
                [1 ]Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; abdohamed481@ 123456yahoo.com (A.H.); ahmedshukri_sci@ 123456yahoo.com (A.S.A.); marcel.frese@ 123456uni-bielefeld.de (M.F.)
                [2 ]Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt; atefel_haddad@ 123456yahoo.com (A.F.E.-H.); tarekmostafaahmedibrahim@ 123456yahoo.com (T.M.A.I.)
                [3 ]Department of Microbial Chemistry, Division of Genetic Engineering and Biotechnology Research, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt
                [4 ]Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; georg.stammler@ 123456uni-bielefeld.de
                [5 ]Department of Chemistry of Natural Compounds, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt
                Author notes
                [* ]Correspondence: norbert.sewald@ 123456uni-bielefeld.de (N.S.); mshaaba@ 123456gmail.com (M.S.); Tel.: +49-521-106-2051 (N.S.); +20-227-01728-1550 (M.S.)
                Author information
                https://orcid.org/0000-0003-4119-7447
                https://orcid.org/0000-0001-7123-1904
                https://orcid.org/0000-0002-0309-2655
                https://orcid.org/0000-0001-9281-2505
                Article
                Publisher ID: molecules-23-00299
                DOI: 10.3390/molecules23020299
                PMC ID: 6017310
                PubMed ID: 29385078
                SO-VID: 62694b85-8fa1-4635-8321-d8a55e7f39b5
                Copyright © © 2018 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 21 December 2017
                Date accepted : 28 January 2018
                Categories
                Subject: Article

                Keywords: nocardiopsis sp. lgo5,terretonin n,6-hydroxymeroterpenoid,antimicrobial activity,cytotoxicity
                Data availability:
                Keywords: nocardiopsis sp. lgo5, terretonin n, 6-hydroxymeroterpenoid, antimicrobial activity, cytotoxicity

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