Association between polymorphism of glutathione S-transferase P1 and chronic obstructive pulmonary disease: A meta-analysis

Abstract

It was proposed that glutathione S-transferase P1 (GSTP1) gene involved in detoxification of electrophilic substances may be related with lung function. The present study aimed at investigating the correlation between GSTP1 105Val/Val genotype and chronic obstruct pulmonary disease (COPD) using a meta-analysis of existed studies. The Embase, Ovid, and PubMed databases were searched to identify eligible studies published before October 1, 2009. Data were extracted using standardized forms and the pooled odds ratios (ORs) with 95% confidence intervals (CI) were assessed by a model of fixed- or random effects. The values of odds ratios(ORs) for COPD were 0.634 (95%CI 0.426-0.943, p = 0.025) in GSTP1 Ile/Ile, 0.625 (95%CI 0.418-0.935, p = 0.022) in GSTP1 Ile/Val, and 0.633 (95% CI 0.430-0.933, p = 0.021) in both, as compared to GSTP1 Val/Val, respectively. The individuals with GSTP1 105Ile/Ile, Ile/Val, and both have about 37% reduction in the odds of COPD, as compared to individuals with GSTP1 105Val/Val. The GSTP1 105Val/Val genotype is suggested to be a genetic contributor to COPD susceptibility, which should be furthermore clarified by studies with large sample sizes and careful control for age, sex, ethnicity, and cigarette smoking. Copyright 2010 Elsevier Ltd. All rights reserved.