A quantitative comparison of anti-Müllerian hormone measurement and its shifting boundaries between two assays.

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Abstract

Anti-Müllerian hormone (AMH), a quantitative marker of ovarian reserve, is used for both clinical and research purposes in the field of reproductive medicine. Numerous AMH assays have been developed. Among other factors, the lack of large-scale comparisons of the various assays hinders the universal interpretation of AMH levels. Moreover, little is known of the practical performance of highly sensitive assays compared with conventional assays with regard to the very low AMH levels found in women nearing menopause. This study aimed to compare the measurements of the Gen II (Beckman Coulter) assay with those of the highly sensitive picoAMH (AnshLabs) assay.

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Author and article information

Journal

Journal ID (iso-abbrev): Maturitas

Title: Maturitas

Publisher: Elsevier BV

ISSN (Electronic): 1873-4111

ISSN (Print): 0378-5122

Publication date (Electronic): Jul 2017

Volume: 101

Affiliations

[1 ] Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address: a.c.dekat@umcutrecht.nl.

[2 ] Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

[3 ] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

[4 ] Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

[5 ] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands.

Article

Publisher Item ID: S0378-5122(17)30115-9

DOI: 10.1016/j.maturitas.2017.04.004

PubMed ID: 28539163

SO-VID: 628d06f5-c265-4c43-9b82-31e5e3ab9eea

History

Keywords: AMH,Assay,Gen II,Ovarian reserve,picoAMH

Data availability:

Keywords: AMH, Assay, Gen II, Ovarian reserve, picoAMH

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