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Consolidation Chemotherapy Prevents Relapse by Indirectly Regulating Bone Marrow Adipogenesis in Patients with Acute Myeloid Leukemia.
Haiyan Liu
1 ,
Yuanmei Zhai
2 ,
Wenli Zhao
3 ,
Yun Wan
1 ,
Wei Lu
1 ,
Shaoxin Yang
1 ,
Yehua Yu
4 ,
Yanyu Wei
1 ,
Zhiqiang Li
5 ,
Jun Shi
1
2018
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Abstract
Chemotherapy is still the main strategy used to prevent the relapse of acute myeloid leukaemia (AML). As the most abundant stromal component in bone marrow (BM), marrow adipocytes have been previously shown to promote leukaemogenesis. The present study was designed to further validate whether marrow adipocytes exert synergistic effects on strengthening chemotherapeutic efficacy and evaluate the underlying mechanism.