Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network.

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Abstract

Intimal sarcoma (InS) is an exceedingly rare neoplasm with an unfavorable prognosis, for which new potentially active treatments are under development. We report on the activity of anthracycline-based regimens, gemcitabine-based regimens, and pazopanib in patients with InS.

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Journal ID (iso-abbrev): Cancer

Title: Cancer

Publisher: Wiley

ISSN (Electronic): 1097-0142

ISSN (Print): 0008-543X

Publication date (Electronic): January 01 2020

Volume: 126

Issue: 1

Affiliations

[1 ] Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale Tumori, Milan, Italy.

[2 ] Department of Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif, France.

[3 ] Unit of Clinical Epidemiology and Trial Organization, IRCCS Fondazione Istituto Nazionale Tumori, Milan, Italy.

[4 ] Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

[5 ] Department of Medical Oncology, Centre Léon Bérard & Université Claude Bernard Lyon I, Lyon, France.

[6 ] Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.

[7 ] Department of Medicine, University of Michigan, Ann Arbor, Michigan.

[8 ] Department of Medicine, Sarcoma Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

[9 ] Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland.

[10 ] Department of Medical Oncology, La Timone University Hospital, Aix-Marseille Université, Marseille, France.

[11 ] Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

[12 ] Department of Medical Oncology, Università Campus Bio-Medico di Roma, Rome, Italy.

[13 ] Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands.

[14 ] Department of Specialized, Experimental and Diagnostic Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

[15 ] Department of Medical Oncology, Nuovo Ospedale "S. Stefano,", Prato, Italy.

[16 ] Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.

[17 ] Department of Medical Oncology, N. N. Blokhin Russian Cancer Research, Moscow, Russian Federation.

[18 ] Medical Oncology, Northwell Cancer Institute and Cold Spring Harbor Laboratory, Long Island, New York.

[19 ] Sarcoma Unit, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, London, United Kingdom.

[20 ] Sarcoma Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

[21 ] Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France.

[22 ] Department of Diagnostic Pathology and Laboratory Medicine, IRCCS Fondazione Istituto Nazionale dei Tumori, Milan, Italy.

[23 ] Department of Pathology, Treviso Regional Hospital, Italy.

[24 ] Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

[25 ] Department of Biopathology, Centre Léon Bérard, Lyon, France.

[26 ] Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.

Article

DOI: 10.1002/cncr.32508

PubMed ID: 31536651

SO-VID: 637aaa2c-9142-4211-a407-2c6128f1c536

History

Keywords: MDM2,anthracycline,gemcitabine,intimal sarcoma,pazopanib,systemic therapies

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Keywords: MDM2, anthracycline, gemcitabine, intimal sarcoma, pazopanib, systemic therapies

Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network.

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