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Migraine
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Abstract
<p class="first" id="d1816444e55">Migraine is a chronic paroxysmal neurological disorder
characterised by multiphase
attacks of head pain and a myriad of neurological symptoms. The underlying genetic
and biological underpinnings and neural networks involved are coming sharply into
focus. This progress in the fundamental understanding of migraine has led to novel,
mechanism-based and disease-specific therapeutics. In this Seminar, the clinical features
and neurobiology of migraine are reviewed, evidence to support available treatment
options is provided, and emerging drug, device, and biological therapies are discussed.
</p>