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      The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.

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      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in common, these two cytokines have contrasting roles in adaptive immune responses. The unique role of interleukin-2 is in the elimination of self-reactive T cells to prevent autoimmunity. By contrast, interleukin-15 is dedicated to the prolonged maintenance of memory T-cell responses to invading pathogens. As discussed in this Review, the biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1733
          1474-1733
          Aug 2006
          : 6
          : 8
          Affiliations
          [1 ] Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. tawald@helix.nih.gov
          Article
          nri1901
          10.1038/nri1901
          16868550
          646b31fd-145e-441c-a6f7-5a7bae78bb84
          History

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