Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates

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Abstract

Formaldehyde (FA) has been implicated in Alzheimer's disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) and tau protein in vitro. Higher levels of FA have also been found in patients with greater cognitive impairment and in AD patient brains.

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Journal

Title: Current Alzheimer Research

Abbreviated Title: CAR

Publisher: Bentham Science Publishers Ltd.

ISSN (Print): 15672050

Publication date Created: November 02 2018

Publication date (Print): November 02 2018

Volume: 15

Issue: 14

Pages: 1304-1321

Affiliations

[1 ]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China

[2 ]Department of Rehabilitation Medicine, Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650021, China

[3 ]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

Article

DOI: 10.2174/1567205015666180904150118

PubMed ID: 30182853

SO-VID: 65020336-f759-48ea-ae34-6c780eddd2ec

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