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      Popliteal arterial thrombosis in nephrotic syndrome: a case report

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          ABSTRACT

          Thrombosis is a frequent cause of morbidity and mortality in patients with nephrotic syndrome (NS). Though venous thromboses are common in NS, arterial thromboses are relatively rare. Commonly involved arteries include coronary, iliac, femoral, renal, cerebral, pulmonary, mesenteric, and axillary arteries, and the aorta. Arterial thromboses are associated with poor prognosis; treatment options are limited and patients may not always be amenable to treatment. We present the case of a 39-year-old female with NS who presented with thigh pain and was found to have sub-acute popliteal artery thrombosis.

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          Risk factors for venous and arterial thrombosis.

          Emanuele Previtali, Paolo Bucciarelli, Serena Passamonti … (2011)
          Article 0 comments Cited 128 times – based on 0 reviews     Review now
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            Nephrotic syndrome: components, connections, and angiopoietin-like 4-related therapeutics.

            Camille Macé, Sumant Chugh (2014)
            Nephrotic syndrome is recognized by the presence of proteinuria in excess of 3.5 g/24 h along with hypoalbuminemia, edema, hyperlipidemia (hypertriglyceridemia and hypercholesterolemia), and lipiduria. Each component has been investigated individually over the past four decades with some success. Studies published recently have started unraveling the molecular basis of proteinuria and its relationship with other components. We now have improved understanding of the threshold for nephrotic-range proteinuria and the pathogenesis of hypertriglyceridemia. These studies reveal that modifying sialylation of the soluble glycoprotein angiopoietin-like 4 or changing key amino acids in its sequence can be used successfully to treat proteinuria. Treatment strategies on the basis of fundamental relationships among different components of nephrotic syndrome use naturally occurring pathways and have great potential for future development into clinically relevant therapeutic agents.
            Article 0 comments Cited 22 times – based on 0 reviews     Review now
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              Arterial thrombosis in the nephrotic syndrome.

              Trevor G. Bell, Kevin McClelland, Dean C Hay … (1994)
              Thrombosis is a frequent cause of morbidity and mortality in patients with the nephrotic syndrome. Venous thrombotic complications are well recognized but arterial complications are rare. Thrombosis is multifactorial, and has been attributed to a hypercoaguable state due to alterations in blood levels of the various factors involved in the coagulation and fibrinolytic systems, alterations in platelet function, venous stasis, haemoconcentration, increased blood viscosity and possibly the administration of steroids. Thrombosis in general and arterial thrombosis in particular is a significant and potentially serious problem in nephrotic patients. Awareness of the condition and its pathogenesis is needed. Assessment for the risk factors is required to allow appropriate prophylactic measures to be taken.
              Article 0 comments Cited 17 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Community Hosp Intern Med Perspect
                Journal ID (iso-abbrev): J Community Hosp Intern Med Perspect
                Journal ID (archive): ZJCH
                Journal ID (publisher-id): zjch20
                Title: Journal of Community Hospital Internal Medicine Perspectives
                Publisher: Taylor & Francis
                ISSN (Electronic): 2000-9666
                Publication date Collection: January 2017
                Publication date (Electronic): 31 March 2017
                Volume: 7
                Issue: 1
                Pages: 34-36
                Affiliations
                [ a ]Department of Medicine, Reading Health System , West Reading, PA, USA
                [ b ]Department of Medicine, Universal College of Medical Sciences , Bhairahawa, Nepal
                Author notes
                CONTACT Niranjan Tachamo niranjantachamo@ 123456gmail.com Department of Medicine, Reading Health System , Sixth Avenue and Spruce St, West Reading, PA, 19611, USA
                Article
                Publisher ID: 1286814
                DOI: 10.1080/20009666.2017.1286814
                PMC ID: 5463665
                PubMed ID: 28634522
                SO-VID: 652815f0-d12e-4b5d-a59a-8e0bc04adae6
                Copyright © © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 October 2016
                Date accepted : 15 December 2016
                Page count
                References: 9, Pages: 3
                Categories
                Subject: Case Report
                Subject: Case Reports

                Keywords: anticoagulation,arterial thrombosis,hypercoagulability,nephrotic syndrome,popliteal artery,steroids,venous thrombosis
                Data availability:
                Keywords: anticoagulation, arterial thrombosis, hypercoagulability, nephrotic syndrome, popliteal artery, steroids, venous thrombosis

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