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      Bacterial Toxins—Staphylococcal Enterotoxin B

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      Microbiology spectrum

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          Abstract

          Staphylococcal enterotoxin B is one of the most potent bacterial superantigens that exerts profound toxic effects upon the immune system, leading to stimulation of cytokine release and inflammation. It is associated with food poisoning, nonmenstrual toxic shock, atopic dermatitis, asthma, and nasal polyps in humans. Currently, there is no treatment or vaccine available. Passive immunotherapy using monoclonal antibodies made in several different species has shown significant inhibition in in vitro studies and reduction in staphylococcal enterotoxin B-induced lethal shock in in vivo studies. This should encourage future endeavors to develop these antibodies as therapeutic reagents.

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          Author and article information

          Journal
          101634614
          42750
          Microbiol Spectr
          Microbiol Spectr
          Microbiology spectrum
          2165-0497
          10 October 2015
          December 2013
          30 October 2016
          : 1
          : 2
          Affiliations
          Department of Medicine/Infectious Diseases and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
          Author notes
          Correspondence: Bettina C. Fries, bettina.fries@ 123456einstein.yu.edu
          Article
          PMC5086421 PMC5086421 5086421 nihpa729221
          10.1128/microbiolspec.AID-0002-2012
          5086421
          26184960
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          Article

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