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      Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmatic Randomized Controlled Trial

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          Abstract

          Chronic musculoskeletal pain affects more than 20% of the population, leading to high health care overload and huge spending. The prevalence is increasing and negatively affects both physical and mental health, being one of the leading causes of disability. The most common location is the spine. Most treatments used in the Public Health Services are passive (pharmacological and invasive) and do not comply with current clinical guidelines, which recommend treating pain in primary care (PC) with education and exercise as the first-line treatments. A randomized multicentre clinical trial has been carried out in 12 PC centres. The experimental group (EG) conducted a program of pain neuroscience education (6 sessions, 10 h) and group physical exercise with playful, dual-tasking, and socialization-promoting components (18 sessions in 6 weeks, 18 h), and the control group performed the usual physiotherapy care performed in PC. The experimental treatment improved quality of life ( d = 1.8 in physical component summary), catastrophism ( d = 1.7), kinesiophobia ( d = 1.8), central sensitization ( d = 1.4), disability ( d = 1.4), pain intensity ( d = 3.3), and pressure pain thresholds ( d = 2). Differences between the groups ( p < 0.001) were clinically relevant in favour of the EG. Improvements post-intervention (week 11) were maintained at six months. The experimental treatment generates high levels of satisfaction.

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          The PRECIS-2 tool: designing trials that are fit for purpose.

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            Chronic back pain is associated with decreased prefrontal and thalamic gray matter density.

            The role of the brain in chronic pain conditions remains speculative. We compared brain morphology of 26 chronic back pain (CBP) patients to matched control subjects, using magnetic resonance imaging brain scan data and automated analysis techniques. CBP patients were divided into neuropathic, exhibiting pain because of sciatic nerve damage, and non-neuropathic groups. Pain-related characteristics were correlated to morphometric measures. Neocortical gray matter volume was compared after skull normalization. Patients with CBP showed 5-11% less neocortical gray matter volume than control subjects. The magnitude of this decrease is equivalent to the gray matter volume lost in 10-20 years of normal aging. The decreased volume was related to pain duration, indicating a 1.3 cm3 loss of gray matter for every year of chronic pain. Regional gray matter density in 17 CBP patients was compared with matched controls using voxel-based morphometry and nonparametric statistics. Gray matter density was reduced in bilateral dorsolateral prefrontal cortex and right thalamus and was strongly related to pain characteristics in a pattern distinct for neuropathic and non-neuropathic CBP. Our results imply that CBP is accompanied by brain atrophy and suggest that the pathophysiology of chronic pain includes thalamocortical processes.
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              Fear-avoidance model of chronic pain: the next generation.

              The fear-avoidance (FA) model of chronic pain describes how individuals experiencing acute pain may become trapped into a vicious circle of chronic disability and suffering. We propose to extend the FA model by adopting a motivational perspective on chronic pain and disability. A narrative review. There is ample evidence to support the validity of the FA model as originally formulated. There are, however, some key challenges that call for a next generation of the FA model. First, the FA model has its roots in psychopathology, and investigators will have to find a way to account for findings that do not easily fit within such framework. Second, the FA model needs to address the dynamics and complexities of disability and functional recovery. Third, the FA model should incorporate the idea that pain-related fear and avoidance occurs in a context of multiple and often competing personal goals. To address these 3 key challenges, we argue that the next generation of the FA model needs to more explicitly adopt a motivational perspective, one that is built around the organizing powers of goals and self-regulatory processes. Using this framework, the FA model is recast as capturing the persistent but futile attempts to solve pain-related problems to protect and restore life goals.
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                Author and article information

                Journal
                J Clin Med
                J Clin Med
                jcm
                Journal of Clinical Medicine
                MDPI
                2077-0383
                22 April 2020
                April 2020
                : 9
                : 4
                : 1201
                Affiliations
                [1 ]Unit for Active Coping Strategies for Pain in Primary Care, East-Valladolid Primary Care Management, Castilla and León Public Health System (Sacyl), 47011 Valladolid, Spain; magalanm@ 123456saludcastillayleon.es (M.A.G.-M.); fmonteroc@ 123456saludcastillayleon.es (F.M.-C.)
                [2 ]Doctoral Program of Research in Health Sciences, University of Valladolid, 47005 Valladolid, Spain
                [3 ]Department of Physical Therapy, University of Valencia, 46010 Valencia, Spain
                [4 ]Pain in Motion International Research Group, 1090 Brussels, Belgium
                [5 ]Department of Human Physiology and Rehabilitation Sciences, Faculty of Physiotherapy, Vrije University Brussels, B-1050 Brussels, Belgium
                [6 ]Castilla and León Regional Centre of Sports Medicine, (Sacyl), 47011 Valladolid, Spain; acuesta.var@ 123456gmail.com
                [7 ]Department of Statistics and Operational Research and IMUVA, University of Valladolid, 47005 Valladolid, Spain
                [8 ]Department of Physiotherapy, Faculty of Heath Sciences, University of Malaga, 19071 Málaga, Spain
                [9 ]Institute of Biomedical Research in Malaga. IBIMA, 29010 Málaga, Spain
                [10 ]School of Clinical Science, Faculty of Health Science, Queensland University Technology, Brisbane, QLD 4000, Australia
                Author notes
                [* ]Correspondence: acuesta@ 123456uma.es
                Author information
                https://orcid.org/0000-0003-0951-6508
                https://orcid.org/0000-0002-8880-4315
                Article
                jcm-09-01201
                10.3390/jcm9041201
                7230486
                32331323
                65772b18-ebc4-4fca-adeb-9c13a6d9d42b
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 18 March 2020
                : 19 April 2020
                Categories
                Article

                chronic pain,chronic spinal pain,pain neuroscience education,physical exercise,primary care,randomized controlled trial

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