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      Bleeding in Renal Failure: Altered Platelet Function in Chronic Uraemia only Partially Corrected by Haemodialysis

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          Abstract

          Bleeding time, blood loss and platelet retention by glass beads, measured by standardized techniques, were significantly altered in a group of 30 non-thrombocytopenic patients with chronic renal failure undergoing maintenance haemodialysis. Bleeding time or blood loss did not correlate with platelet retention either before or after haemodialysis. No correlation could be found between the above tests and a number of biochemical parameters characterizing the uraemic condition. Haemodialysis only partially corrected the abnormal bleeding time, blood loss and platelet retention. These tests were still significantly different after haemodialysis from those of 30 normal subjects. It is suggested that some non-dialyzable material could play an important role in the aetiology of uraemic bleeding.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 4-6
          : 347-353
          Affiliations
          Nephrology and Dialysis Division, Laboratory of Clinical Chemistry, Ospedali Riuniti, Bergamo, and Laboratory of Cardiovascular Clinical Pharmacology, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan
          Article
          181474 Nephron 1978;22:347–353
          10.1159/000181474
          740096
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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