Cytotoxic tumour-infiltrating T lymphocytes influence outcome in resected pancreatic ductal adenocarcinoma.

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Abstract

We studied the prognostic effect of CD3-, CD8- and CD103-positive T lymphocytes in a cohort of 165 patients with resected pancreatic ductal adenocarcinomas (PDACs) of the treatment group (adjuvant gemcitabine) and the untreated control group of the CONKO-001 study.

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Journal

Journal ID (iso-abbrev): Eur. J. Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): September 2017

Volume: 83

Affiliations

[1 ] Universitätsmedizin Charité Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: philipp.lohneis@charite.de.

[2 ] Universitätsmedizin Charité Berlin, CONKO Study Group, Department of Medical Oncology, Haematology and Tumorimmunology, Augustenburger Platz 1, 13353 Berlin, Germany.

[3 ] Universitätsmedizin Charité Berlin, Department of General, Visceral and Transplantation Surgery, Augustenburger Platz 1, 13353 Berlin, Germany.

[4 ] Universitätsmedizin Charité Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany.

[5 ] Outpatient Department Hematology/Oncology, Friedrichstrasse 53, 88045 Friedrichshafen, Germany.

Article

Publisher Item ID: S0959-8049(17)31067-5

DOI: 10.1016/j.ejca.2017.06.016

PubMed ID: 28772128

SO-VID: 66aee2ea-fd81-4125-8a6f-d83fa67ba13f

History

Keywords: Tumour-infiltrating lymphocytes,CD3,CD8,Gemcitabine,Pancreatic cancer,T lymphocytes,CD103

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Keywords: Tumour-infiltrating lymphocytes, CD3, CD8, Gemcitabine, Pancreatic cancer, T lymphocytes, CD103

Cytotoxic tumour-infiltrating T lymphocytes influence outcome in resected pancreatic ductal adenocarcinoma.

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Abstract

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Regulatory T cell (Treg) therapy

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