The neutrophil in vascular inflammation

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Abstract

Here we focus on how neutrophils have a key regulatory role in vascular inflammation. Recent studies using advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these processes may be disrupted in systemic infections, with a particular emphasis on mouse models of sepsis. Neutrophils are often immobilized in the lungs and liver during systemic infections, and this immobilization may be a mechanism through which bacteria can evade the innate immune response or allow neutrophils to form neutrophil extracellular traps that trap and kill bacteria in blood. The platelet is also an important player in sepsis, and we describe how it collaborates with neutrophils in the formation of neutrophil extracellular traps.

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The online version of this article (doi:10.1038/nm.2514) contains supplementary material, which is available to authorized users.

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Author and article information

Contributors

Paul Kubes: pkubes@ucalgary.ca

Journal

Journal ID (nlm-ta): Nat Med

Journal ID (iso-abbrev): Nat. Med

Title: Nature Medicine

Publisher: Nature Publishing Group US (New York )

ISSN (Print): 1078-8956

ISSN (Electronic): 1546-170X

Publication date (Electronic): 7 November 2011

Publication date (Print): 2011

Volume: 17

Issue: 11

Pages: 1381-1390

Affiliations

[1 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Department of Medical Cell Biology, Division of Integrative Physiology, , Uppsala University, ; Uppsala, Sweden

[2 ]GRID grid.22072.35, ISNI 0000 0004 1936 7697, Department of Physiology and Pharmacology, , Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, ; Calgary, Alberta Canada

Article

Publisher ID: BFnm2514

DOI: 10.1038/nm.2514

PMC ID: 7095830

PubMed ID: 22064428

SO-VID: 66e4c7ee-58a5-4a8a-ba61-dd7412eb2e88

License:

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.