lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA.

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Abstract

Pathological angiogenesis is a critical component of diseases, such as ocular disorders, cancers, and atherosclerosis. It is usually caused by the abnormal activity of biological processes, such as cell proliferation, cell motility, immune, or inflammation response. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of these biological processes. However, the role of lncRNA in diabetes mellitus-induced microvascular dysfunction is largely unknown.

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Journal

Journal ID (iso-abbrev): Circ. Res.

Title: Circulation research

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Mar 27 2015

Volume: 116

Issue: 7

Affiliations

[1 ] From the Department of Central Laboratory, Eye Hospital (B.Y., J.-Y.L., J.Y., X.-M.L., X.-Q.W., Y.-J.L., Z.-F.T., Y.-C.S., Q.J.), Department of Ophthalmology, The Fourth School of Clinical Medicine (B.Y., J.Y., Q.J.), and Department of Pathophysiology, School of Basic Medical Sciences (Q.C.), Nanjing Medical University, Nanjing, China. yanbiao1982@hotmail.com jqin710@vip.sina.com.cn.

[2 ] From the Department of Central Laboratory, Eye Hospital (B.Y., J.-Y.L., J.Y., X.-M.L., X.-Q.W., Y.-J.L., Z.-F.T., Y.-C.S., Q.J.), Department of Ophthalmology, The Fourth School of Clinical Medicine (B.Y., J.Y., Q.J.), and Department of Pathophysiology, School of Basic Medical Sciences (Q.C.), Nanjing Medical University, Nanjing, China.

Article

Publisher Item ID: CIRCRESAHA.116.305510

DOI: 10.1161/CIRCRESAHA.116.305510

PubMed ID: 25587098

SO-VID: 671fc1df-de9e-4f18-ae30-707d67175d41

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Keywords: angiogenesis inhibitors,epigenomics,long noncoding RNA,vascular endothelial growth factor

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Keywords: angiogenesis inhibitors, epigenomics, long noncoding RNA, vascular endothelial growth factor

lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA.

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