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Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab.
Heloisa Sawaya
1 ,
Igal A Sebag ,
Juan Carlos Plana ,
James L Januzzi ,
Bonnie Ky ,
Timothy C Tan ,
Victor Cohen ,
Jose Banchs ,
Joseph R Carver ,
Susan E Wiegers ,
Randolph P Martin ,
Michael H Picard ,
Robert E Gerszten ,
Elkan F Halpern ,
Jonathan Passeri ,
Irene Kuter ,
Marielle Scherrer-Crosbie
Sep 01 2012
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Abstract
Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab.