9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Adherence of North-African Pulmonologists to the 2017-Global Initiative for Chronic Obstructive Lung Disease (GOLD) Pharmacological Treatment Guidelines (PTGs) of Stable Chronic Obstructive Pulmonary Disease (COPD)

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          No previous study has investigated the adherence rate of North-African pulmonologists to the 2017-GOLD PTGs.

          Aims

          To investigate the adherence rate of Tunisian pulmonologists to the 2017-GOLD PTGs and to identify the barriers to their adherence.

          Methods

          This was a cohort study involving clinically stable COPD patients who presented to a pulmonology outpatient consultation. The patients were classified as having been appropriately and inappropriately (over- or undertreatment) treated for the GOLD group. Logistic regression was performed to determine the adherence barriers to the 2017-GOLD PTGs.

          Results

          A total of 296 patients were included (88.1% males, mean age: 68 ± 10 years; GOLD A (7.1%), B (36.1%), C (4.1%), and D (52.7%)). The pulmonologists' adherence rate to the 2017-GOLD PTGs was 29.7%. There was a significant statistical difference between the adherence rates among the four GOLD groups (A: 19.0%, B: 20.6%, C: 8.3%, and D: 39.1%; p = 0.001). Differences were statistically significant between the GOLD group D and groups B ( p = 0.001). Differences were statistically significant between the GOLD group D and groups B ( p = 0.001). Differences were statistically significant between the GOLD group D and groups B (

          Conclusion

          The adherence rate of Tunisian pulmonologists to the 2017-GOLD PTGs is low. It seems that the patients' age, socioeconomic level, national health insurance coverage, and GOLD groups influenced their adherence.

          Related collections

          Most cited references47

          • Record: found
          • Abstract: found
          • Article: not found

          Susceptibility to exacerbation in chronic obstructive pulmonary disease.

          Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete. In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity. We analyzed the frequency and associations of exacerbation in 2138 patients enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study. Exacerbations were defined as events that led a care provider to prescribe antibiotics or corticosteroids (or both) or that led to hospitalization (severe exacerbations). Exacerbation frequency was observed over a period of 3 years. Exacerbations became more frequent (and more severe) as the severity of COPD increased; exacerbation rates in the first year of follow-up were 0.85 per person for patients with stage 2 COPD (with stage defined in accordance with Global Initiative for Chronic Obstructive Lung Disease [GOLD] stages), 1.34 for patients with stage 3, and 2.00 for patients with stage 4. Overall, 22% of patients with stage 2 disease, 33% with stage 3, and 47% with stage 4 had frequent exacerbations (two or more in the first year of follow-up). The single best predictor of exacerbations, across all GOLD stages, was a history of exacerbations. The frequent-exacerbation phenotype appeared to be relatively stable over a period of 3 years and could be predicted on the basis of the patient's recall of previous treated events. In addition to its association with more severe disease and prior exacerbations, the phenotype was independently associated with a history of gastroesophageal reflux or heartburn, poorer quality of life, and elevated white-cell count. Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype. This has implications for the targeting of exacerbation-prevention strategies across the spectrum of disease severity. (Funded by GlaxoSmithKline; ClinicalTrials.gov number, NCT00292552.)
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: found

              Cohort Studies: Prospective versus Retrospective

              Cohort studies form a suitable study design to assess associations between multiple exposures on the one hand and multiple outcomes on the other hand. They are especially appropriate to study rare exposures or exposures for which randomization is not possible for practical or ethical reasons. Prospective and retrospective cohort studies have higher accuracy and higher efficiency as their respective main advantages. In addition to possible confounding by indication, cohort studies may suffer from selection bias. Confounding and bias should be prevented whenever possible, but still can exert unknown effects in unknown directions. If one is aware of this, cohort studies can form a potent study design in nephrology producing, in general, highly generalizable results.
                Bookmark

                Author and article information

                Contributors
                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi
                2314-6133
                2314-6141
                2020
                28 February 2020
                : 2020
                : 1031845
                Affiliations
                1Department of Pneumology, Farhat Hached University Hospital in Sousse, Tunisia
                2Interaction of the Cardiorespiratory System (LR14ES05) Research Laboratory, Faculty of Medicine of Sousse, University of Sousse, Tunisia
                3Université de Sousse, Faculté de Médecine de Sousse, Département d'épidémiologie, Hôpital Farhat Hached, Sousse, Tunisia
                4Medical Intensive Care Unit, Farhat Hached University Hospital in Sousse, Tunisia
                5Physiology Laboratory, Faculty of Medicine of Sousse, University of Sousse, Tunisia
                6Department of Physiology and Functional Exploration, Farhat Hached University Hospital in Sousse, Tunisia
                7Heart Failure (LR12SP09) Research Laboratory, Farhat Hached University Hospital in Sousse, Tunisia
                Author notes

                Academic Editor: Noriyoshi Sawabata

                Author information
                https://orcid.org/0000-0001-6164-9071
                https://orcid.org/0000-0001-8857-2238
                https://orcid.org/0000-0002-7477-2965
                Article
                10.1155/2020/1031845
                7066397
                32190644
                69371e62-7c05-43ee-8f52-1131c4ff374d
                Copyright © 2020 Sana Aissa et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 6 November 2019
                : 13 February 2020
                : 17 February 2020
                Categories
                Research Article

                Comments

                Comment on this article