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Early prediction of response to sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound.
Maria Assunta Zocco
1 ,
Matteo Garcovich ,
Andrea Lupascu ,
Enrico Di Stasio ,
Davide Roccarina ,
Brigida Elenora Annicchiarico ,
Laura Riccardi ,
Maria Elena Ainora ,
Francesca Ponziani ,
Gianluigi Caracciolo ,
Gian Lodovico Rapaccini ,
Raffaele Landolfi ,
Massimo Siciliano ,
Maurizio Pompili ,
Antonio Gasbarrini
Nov 2013
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Abstract
Sorafenib has become the standard first-line treatment for patients with advanced HCC and acts by inducing alterations in tumor vascularity. We wanted to evaluate the feasibility of dynamic CEUS (D-CEUS) as a predictor of early tumor response to sorafenib and to correlate functional parameters with clinical efficacy end points.