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      List-wise learning to rank biomedical question-answer pairs with deep ranking recursive autoencoders

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          Abstract

          Biomedical question answering (QA) represents a growing concern among industry and academia due to the crucial impact of biomedical information. When mapping and ranking candidate snippet answers within relevant literature, current QA systems typically refer to information retrieval (IR) techniques: specifically, query processing approaches and ranking models. However, these IR-based approaches are insufficient to consider both syntactic and semantic relatedness and thus cannot formulate accurate natural language answers. Recently, deep learning approaches have become well-known for learning optimal semantic feature representations in natural language processing tasks. In this paper, we present a deep ranking recursive autoencoders (rankingRAE) architecture for ranking question-candidate snippet answer pairs (Q-S) to obtain the most relevant candidate answers for biomedical questions extracted from the potentially relevant documents. In particular, we convert the task of ranking candidate answers to several simultaneous binary classification tasks for determining whether a question and a candidate answer are relevant. The compositional words and their random initialized vectors of concatenated Q-S pairs are fed into recursive autoencoders to learn the optimal semantic representations in an unsupervised way, and their semantic relatedness is classified through supervised learning. Unlike several existing methods to directly choose the top-K candidates with highest probabilities, we take the influence of different ranking results into consideration. Consequently, we define a listwise “ranking error” for loss function computation to penalize inappropriate answer ranking for each question and to eliminate their influence. The proposed architecture is evaluated with respect to the BioASQ 2013-2018 Six-year Biomedical Question Answering benchmarks. Compared with classical IR models, other deep representation models, as well as some state-of-the-art systems for these tasks, the experimental results demonstrate the robustness and effectiveness of rankingRAE.

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          Neural machine translation by jointly learning to align and translate

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            Knowledge Discovery and interactive Data Mining in Bioinformatics - State-of-the-Art, future challenges and research directions

            Computers are incredibly fast, accurate, and stupid. Human beings are incredibly slow, inaccurate, and brilliant. Together they are powerful beyond imagination (Einstein never said that [1]).
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              Biomedical question answering: a survey.

              In this survey, we reviewed the current state of the art in biomedical QA (Question Answering), within a broader framework of semantic knowledge-based QA approaches, and projected directions for the future research development in this critical area of intersection between Artificial Intelligence, Information Retrieval, and Biomedical Informatics. We devised a conceptual framework within which to categorize current QA approaches. In particular, we used "semantic knowledge-based QA" as a category under which to subsume QA techniques and approaches, both corpus-based and knowledge base (KB)-based, that utilize semantic knowledge-informed techniques in the QA process, and we further classified those approaches into three subcategories: (1) semantics-based, (2) inference-based, and (3) logic-based. Based on the framework, we first conducted a survey of open-domain or non-biomedical-domain QA approaches that belong to each of the three subcategories. We then conducted an in-depth review of biomedical QA, by first noting the characteristics of, and resources available for, biomedical QA and then reviewing medical QA approaches and biological QA approaches, in turn. The research articles reviewed in this paper were found and selected through online searches. Our review suggested the following tasks ahead for the future research development in this area: (1) Construction of domain-specific typology and taxonomy of questions (biological QA), (2) Development of more sophisticated techniques for natural language (NL) question analysis and classification, (3) Development of effective methods for answer generation from potentially conflicting evidences, (4) More extensive and integrated utilization of semantic knowledge throughout the QA process, and (5) Incorporation of logic and reasoning mechanisms for answer inference. Corresponding to the growth of biomedical information, there is a growing need for QA systems that can help users better utilize the ever-accumulating information. Continued research toward development of more sophisticated techniques for processing NL text, for utilizing semantic knowledge, and for incorporating logic and reasoning mechanisms, will lead to more useful QA systems. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: InvestigationRole: SoftwareRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: Investigation
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                2020
                9 November 2020
                : 15
                : 11
                : e0242061
                Affiliations
                [1 ] Department of Computer Science and Technology, School of Mechanical Electronic and Information Engineering, China University of Mining and Technology Beijing, Beijing, China
                [2 ] Alibaba Group, Hangzhou, China
                University of Lisbon, PORTUGAL
                Author notes

                Competing Interests: We have the following interests: (BZ) is employed by Alibaba Group. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

                Author information
                https://orcid.org/0000-0002-0187-7010
                Article
                PONE-D-19-28201
                10.1371/journal.pone.0242061
                7652278
                33166367
                6a1cebaa-f443-4f29-a698-bfa040b6df47
                © 2020 Yan et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 30 October 2019
                : 26 October 2020
                Page count
                Figures: 4, Tables: 8, Pages: 19
                Funding
                The funder, Aibaba Group, provided support in the form of salaries for authors [BZ], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section, and we don’t have any funding.
                Categories
                Research Article
                Research and Analysis Methods
                Database and Informatics Methods
                Information Retrieval
                Social Sciences
                Linguistics
                Semantics
                Computer and Information Sciences
                Neural Networks
                Recurrent Neural Networks
                Biology and Life Sciences
                Neuroscience
                Neural Networks
                Recurrent Neural Networks
                Social Sciences
                Linguistics
                Grammar
                Syntax
                Computer and Information Sciences
                Neural Networks
                Biology and Life Sciences
                Neuroscience
                Neural Networks
                Medicine and Health Sciences
                Physical Sciences
                Mathematics
                Statistics
                Similarity Measures
                Cosine Similarity
                Social Sciences
                Linguistics
                Languages
                Natural Language
                Custom metadata
                All relevant data are within the paper and its Supporting information files.

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