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Generalized Myasthenia Gravis
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Abstract
Myasthenia gravis (MG) is a rare disease, but the most common disorder of the neuromuscular
junction. It is the prototypic autoimmune disease most commonly caused by antibodies
to the acetylcholine receptor (AChR) leading to characteristic fatigable weakness
of the ocular, bulbar, respiratory, axial, and limb muscles. The majority of patients
with MG first present with ocular symptoms. Most patients with MG will experience
at least 1 exacerbation of symptoms throughout the course of their illness. This article
will cover the epidemiology, clinical presentation, classification, and natural history
of MG.