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Use of misoprostol during pregnancy and Möbius' syndrome in infants.
A L Pastuszak
1 ,
L Schüler ,
C E Speck-Martins ,
K E Coelho ,
S M Cordello ,
F Vargas ,
D Brunoni ,
I V Schwarz ,
M Larrandaburu ,
H Safattle ,
V F Meloni ,
G Koren
Jun 25 1998
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Abstract
Patients with upper gastrointestinal ulceration may be treated with misoprostol, but it is not recommended for pregnant women because it may stimulate uterine contractions and cause vaginal bleeding and miscarriage. Recent data from Brazil, where misoprostol is used orally and vaginally as an abortifacient, have suggested a relation between the use of misoprostol by women in an unsuccessful attempt to terminate pregnancy and Möbius' syndrome (congenital facial paralysis) in their infants.