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      Predictors associated with unplanned hospital readmission of medical and surgical intensive care unit survivors within 30 days of discharge

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          Abstract

          Background

          Reducing the 30-day unplanned hospital readmission rate is a goal for physicians and policymakers in order to improve quality of care. However, data on the readmission rate of critically ill patients in Japan and knowledge of the predictors associated with readmission are lacking. We investigated predictors associated with 30-day rehospitalization for medical and surgical adult patients separately.

          Methods

          Patient data from 502 acute care hospitals with intensive care unit (ICU) facilities in Japan were retrospectively extracted from the Japanese Diagnosis Procedure Combination (DPC) database between April 2012 and February 2014. Factors associated with unplanned hospital readmission within 30 days of hospital discharge among medical and surgical ICU survivors were identified using multivariable logistic regression analysis.

          Results

          Of 486,651 ICU survivors, we identified 5583 unplanned hospital readmissions within 30 days of discharge following 147,423 medical hospitalizations (3.8% readmitted) and 11,142 unplanned readmissions after 339,228 surgical hospitalizations (3.3% readmitted). The majority of unplanned hospital readmissions, 60.9% of medical and 63.1% of surgical case readmissions, occurred within 15 days of discharge. For both medical and surgical patients, the Charlson comorbidity index score; category of primary diagnosis during the index admission (respiratory, gastrointestinal, and metabolic and renal); hospital length of stay; discharge to skilled nursing facilities; and having received a packed red blood cell transfusion, low-dose steroids, or renal replacement therapy were significantly associated with higher unplanned hospital readmission rates.

          Conclusions

          From patient data extracted from a large Japanese national database, the 30-day unplanned hospital readmission rate after ICU stay was 3.4%. Further studies are required to improve readmission prediction models and to develop targeted interventions for high-risk patients.

          Electronic supplementary material

          The online version of this article (10.1186/s40560-018-0284-x) contains supplementary material, which is available to authorized users.

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          Most cited references26

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          Post-hospital syndrome--an acquired, transient condition of generalized risk.

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            Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community.

            Readmissions to hospital are common, costly and often preventable. An easy-to-use index to quantify the risk of readmission or death after discharge from hospital would help clinicians identify patients who might benefit from more intensive post-discharge care. We sought to derive and validate an index to predict the risk of death or unplanned readmission within 30 days after discharge from hospital to the community. In a prospective cohort study, 48 patient-level and admission-level variables were collected for 4812 medical and surgical patients who were discharged to the community from 11 hospitals in Ontario. We used a split-sample design to derive and validate an index to predict the risk of death or nonelective readmission within 30 days after discharge. This index was externally validated using administrative data in a random selection of 1,000,000 Ontarians discharged from hospital between 2004 and 2008. Of the 4812 participating patients, 385 (8.0%) died or were readmitted on an unplanned basis within 30 days after discharge. Variables independently associated with this outcome (from which we derived the mnemonic "LACE") included length of stay ("L"); acuity of the admission ("A"); comorbidity of the patient (measured with the Charlson comorbidity index score) ("C"); and emergency department use (measured as the number of visits in the six months before admission) ("E"). Scores using the LACE index ranged from 0 (2.0% expected risk of death or urgent readmission within 30 days) to 19 (43.7% expected risk). The LACE index was discriminative (C statistic 0.684) and very accurate (Hosmer-Lemeshow goodness-of-fit statistic 14.1, p=0.59) at predicting outcome risk. The LACE index can be used to quantify risk of death or unplanned readmission within 30 days after discharge from hospital. This index can be used with both primary and administrative data. Further research is required to determine whether such quantification changes patient care or outcomes.
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              Proportion of hospital readmissions deemed avoidable: a systematic review.

              Readmissions to hospital are increasingly being used as an indicator of quality of care. However, this approach is valid only when we know what proportion of readmissions are avoidable. We conducted a systematic review of studies that measured the proportion of readmissions deemed avoidable. We examined how such readmissions were measured and estimated their prevalence. We searched the MEDLINE and EMBASE databases to identify all studies published from 1966 to July 2010 that reviewed hospital readmissions and that specified how many were classified as avoidable. Our search strategy identified 34 studies. Three of the studies used combinations of administrative diagnostic codes to determine whether readmissions were avoidable. Criteria used in the remaining studies were subjective. Most of the studies were conducted at single teaching hospitals, did not consider information from the community or treating physicians, and used only one reviewer to decide whether readmissions were avoidable. The median proportion of readmissions deemed avoidable was 27.1% but varied from 5% to 79%. Three study-level factors (teaching status of hospital, whether all diagnoses or only some were considered, and length of follow-up) were significantly associated with the proportion of admissions deemed to be avoidable and explained some, but not all, of the heterogeneity between the studies. All but three of the studies used subjective criteria to determine whether readmissions were avoidable. Study methods had notable deficits and varied extensively, as did the proportion of readmissions deemed avoidable. The true proportion of hospital readmissions that are potentially avoidable remains unclear.
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                Author and article information

                Contributors
                tohnuma@email.unc.edu
                d-shinjo@umin.ac.jp
                abrookhart@unc.edu
                +81-3-5803-4025 , kfushimi.hci@tmd.ac.jp
                Journal
                J Intensive Care
                J Intensive Care
                Journal of Intensive Care
                BioMed Central (London )
                2052-0492
                1 March 2018
                1 March 2018
                2018
                : 6
                : 14
                Affiliations
                [1 ]ISNI 0000 0001 1014 9130, GRID grid.265073.5, Department of Health Policy and Informatics, , Tokyo Medical and Dental University Graduate School, ; 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138519 Japan
                [2 ]ISNI 0000 0001 1034 1720, GRID grid.410711.2, Department of Epidemiology, Gillings School of Global Public Health, , University of North Carolina, ; Chapel Hill, USA
                [3 ]ISNI 0000 0004 1764 7572, GRID grid.412708.8, The Database Center of the National University Hospital, , The University of Tokyo Hospital, ; Tokyo, Japan
                Author information
                http://orcid.org/0000-0002-1894-0290
                Article
                284
                10.1186/s40560-018-0284-x
                5831844
                29507728
                6dcdb3f4-6f10-41a4-bba5-1add6c7f2418
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 16 January 2018
                : 19 February 2018
                Funding
                Funded by: Grants-in-Aid for Research on Policy Planning and Evaluation
                Award ID: H26-SEISAKU-SITEI-011
                Award Recipient :
                Funded by: the 19th Grant of the Institute for Health Economics and Policy
                Categories
                Research
                Custom metadata
                © The Author(s) 2018

                hospital readmission,rehospitalizations,intensive care unit,critical illness,predictors,outcomes research

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