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      The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral budding, it mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane. The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Mar 26 2009
          : 458
          : 7237
          Affiliations
          [1 ] Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway.
          Article
          nature07961
          10.1038/nature07961
          19325624
          6e3a50a0-508d-4135-be0e-d0d4d240cbf9
          History

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