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      BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.

      1 , , , , , , , , , ,

      The Journal of thoracic and cardiovascular surgery

      29, 33.1, CMV, Dox, EC, ENOS, FITC, GAPDH, GFP, HUVEC, ICAM-1, MOI, PCR, PFU, ROS, SNP, TNFα, VCAM-1, VEGF, ad, adenovirus, cytomegalovirus, doxorubicin, endothelial cell, endothelial nitric oxide synthase, fluorescein isothiocyanate, glyceraldehyde 3-phosphate dehydrogenase, green fluorescent protein, human umbilical vein endothelial cell, intercellular adhesion molecule 1, multiplicity of infection, oxLDL, oxidized low-density lipoprotein, plaque-forming unit, polymerase chain reaction, reactive oxygen species, siRNA, single nucleotide polymorphism, small interfering RNA, tumor necrosis factor-alpha, vascular cell adhesion molecule 1, vascular endothelial growth factor

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          Abstract

          BRCA1, a tumor suppressor gene implicated in breast and ovarian cancers, exerts multiple effects on DNA repair and affords resistance against cellular stress responses. We hypothesized that BRCA1 limits endothelial cell apoptosis and dysfunction, and via this mechanism attenuates atherosclerosis.

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          Author and article information

          Journal
          J. Thorac. Cardiovasc. Surg.
          The Journal of thoracic and cardiovascular surgery
          1097-685X
          0022-5223
          Oct 2013
          : 146
          : 4
          Affiliations
          [1 ] Division of Cardiac Surgery, Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, Ontario, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, Ontario, Canada.
          Article
          S0022-5223(12)01650-9
          10.1016/j.jtcvs.2012.12.064
          23415688
          Copyright © 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

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