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BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.
Krishna K Singh
1 ,
Praphulla C Shukla ,
Adrian Quan ,
Mohammed Al-Omran ,
Fina Lovren ,
Yi Pan ,
Christine Brezden-Masley ,
Alistair J Ingram ,
William L Stanford ,
Hwee Teoh ,
Subodh Verma
Oct 2013
29,
33.1,
CMV,
Dox,
EC,
ENOS,
FITC,
GAPDH,
GFP,
HUVEC,
ICAM-1,
MOI,
PCR,
PFU,
ROS,
SNP,
TNFα,
VCAM-1,
VEGF,
ad,
adenovirus,
cytomegalovirus,
doxorubicin,
endothelial cell,
endothelial nitric oxide synthase,
fluorescein isothiocyanate,
glyceraldehyde 3-phosphate dehydrogenase,
green fluorescent protein,
human umbilical vein endothelial cell,
intercellular adhesion molecule 1,
multiplicity of infection,
oxLDL,
oxidized low-density lipoprotein,
plaque-forming unit,
polymerase chain reaction,
reactive oxygen species,
siRNA,
single nucleotide polymorphism,
small interfering RNA,
tumor necrosis factor-alpha,
vascular cell adhesion molecule 1,
vascular endothelial growth factor
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Abstract
BRCA1, a tumor suppressor gene implicated in breast and ovarian cancers, exerts multiple effects on DNA repair and affords resistance against cellular stress responses. We hypothesized that BRCA1 limits endothelial cell apoptosis and dysfunction, and via this mechanism attenuates atherosclerosis.
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Author and article information
29,33.1,CMV,Dox,EC,ENOS,FITC,GAPDH,GFP,HUVEC,ICAM-1,MOI,PCR,PFU,ROS,SNP,TNFα,VCAM-1,VEGF,ad,adenovirus,cytomegalovirus,doxorubicin,endothelial cell,endothelial nitric oxide synthase,fluorescein isothiocyanate,glyceraldehyde 3-phosphate dehydrogenase,green fluorescent protein,human umbilical vein endothelial cell,intercellular adhesion molecule 1,multiplicity of infection,oxLDL,oxidized low-density lipoprotein,plaque-forming unit,polymerase chain reaction,reactive oxygen species,siRNA,single nucleotide polymorphism,small interfering RNA,tumor necrosis factor-alpha,vascular cell adhesion molecule 1,vascular endothelial growth factor
29, 33.1, CMV, Dox, EC, ENOS, FITC, GAPDH, GFP, HUVEC, ICAM-1, MOI, PCR, PFU, ROS, SNP, TNFα, VCAM-1, VEGF, ad, adenovirus, cytomegalovirus, doxorubicin, endothelial cell, endothelial nitric oxide synthase, fluorescein isothiocyanate, glyceraldehyde 3-phosphate dehydrogenase, green fluorescent protein, human umbilical vein endothelial cell, intercellular adhesion molecule 1, multiplicity of infection, oxLDL, oxidized low-density lipoprotein, plaque-forming unit, polymerase chain reaction, reactive oxygen species, siRNA, single nucleotide polymorphism, small interfering RNA, tumor necrosis factor-alpha, vascular cell adhesion molecule 1, vascular endothelial growth factor