Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in T cell acute lymphoblastic leukemia.

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Abstract

BCL11B overexpression is a characteristic of most T cell acute lymphoblastic leukemia (T-ALL) cases, and downregulated BCL11B in leukemic T cells inhibits cell proliferation and induces apoptosis. The purpose of this study was to analyze the miRNA expression pattern that may be related to BCL11B regulation in T-ALL.

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Author and article information

Journal

Journal ID (iso-abbrev): Asia Pac J Clin Oncol

Title: Asia-Pacific journal of clinical oncology

Publisher: Wiley

ISSN (Electronic): 1743-7563

ISSN (Print): 1743-7555

Publication date (Electronic): Oct 2018

Volume: 14

Issue: 5

Affiliations

[1 ] Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China.

[2 ] Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China.

Article

DOI: 10.1111/ajco.12979

PubMed ID: 29749698

SO-VID: 715af6ec-5da8-44c5-802c-2b48c5d12c2a

History

Keywords: BCL11B,T-ALL,miR-17,miR-214,miR-29c,miR-92a

Data availability:

Keywords: BCL11B, T-ALL, miR-17, miR-214, miR-29c, miR-92a

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Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in T cell acute lymphoblastic leukemia.

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