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      Hydralazine Prevents Changes in the Contractile Response of Aortic but Not Portal Vein Strips in Hypertensive Rats


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          Previous studies showed that aortic strips from rats with either spontaneous (SHR) or DOCA/salt-induced hypertension developed less stress (force/area) in response to noradrenaline (NA) when compared to aortic strips from normotensive rats. Portal vein strips from SHR, but not from DOCA/salt hypertensive rats, developed greater force to NA compared to strips from control rats. We have investigated whether these changes are prevented by hydralazine. Hydralazine was added to the drinking solution (1% NACl) of one group of rats from the first day of treatment with DOCA. In the second group, hydralazine was added to the drinking water of 13-week-old SHR. After 3 weeks of treatment with hydralazine, cumulative dose-response relationships to NA were studied using aortic and portal vein strips from hydralazine-treated and control rats. Hydralazine prevented the increase of arterial pressure and the decrease of stress developed to NA by the aortic strips from both SHR and DOCA/salt rats. It did not prevent the increase of force developed to NA by the portal vein strips from SHR. Thus, reduced contractile response of the aortic strips from hypertensive rats seems to be the result of a high pressure, since both the rise in blood pressure and reduced aortic response are prevented by hydralazine. Increased contractile response of the portal vein strips from SHR appears to be independent of blood pressure.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 17
          : 6
          : 293-301
          Faculty of Medicine, The University of British Columbia, Vancouver, B.C.
          158260 Blood Vessels 1980;17:293–301
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 17 September 1979
          : 07 February 1980
          Page count
          Pages: 9
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Calcium,Contractile response,Vascular smooth muscle,Hydralazine,Noradrenaline,Hypertension


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