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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Hubert Plovier ,
Amandine Everard ,
Céline Druart ,
Clara Depommier ,
Matthias Van Hul ,
Lucie Geurts ,
Julien Chilloux ,
Noora Ottman ,
Thibaut Duparc ,
Laeticia Lichtenstein ,
Antonis Myridakis ,
Nathalie M Delzenne ,
Judith Klievink ,
Arnab Bhattacharjee ,
Kees C H van der Ark ,
Steven Aalvink ,
Laurent O Martinez ,
Marc-Emmanuel Dumas ,
Dominique Maiter ,
Audrey Loumaye ,
Michel P Hermans ,
Jean-Paul Thissen ,
Clara Belzer ,
Willem M de Vos ,
Patrice D Cani
November 28 2016
November 28 2016
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Abstract
Akkermansia muciniphila, a member of the gut microbiome, has been shown to improve metabolism in mice. Here it is reported that its pasteurization further improves this effect, and that one of its membrane proteins by itself has a similar benefit.