Enzymatic Versus Traditional Surgical Debridement of Severely Burned Hands : A Comparison of Selectivity, Efficacy, Healing Time, and Three-Month Scar Quality

Excisional debridement followed by autografting is the standard of care (SOC) for deep burns, but is associated with serious potential complications. Conservative, non-surgical and current enzymatic debridement methods are inefficiently slow. We determined whether a non-surgical option of rapid enzymatic debridement with the debriding enzyme NexoBrid™ (NXB) would reduce need for surgery while achieving similar esthetic and functional outcomes as SOC.